(E)-(9H-fluoren-9-yl)methyl 2-butylidenehydrazinecarboxylate | 1338091-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (E)-(9H-fluoren-9-yl)methyl 2-butylidenehydrazinecarboxylate
• 英文别名: 9H-fluoren-9-ylmethyl N-[(E)-butylideneamino]carbamate
• CAS: 1338091-81-8
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.38
• InChiKey: OQGVRQWLSWAUTC-UDWIEESQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯甲酸-9-芴基甲酯 在 一水合肼 作用下， 以 水 、 乙腈 为溶剂， 反应 2.0h， 生成 (E)-(9H-fluoren-9-yl)methyl 2-butylidenehydrazinecarboxylate
  参考文献：
  名称：

  Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

  摘要：

  A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.056

文献信息

• STABLE PEPTIDE-BASED FURIN INHIBITORS
  申请人：Day Robert

  公开号：US20150141324A1

  公开（公告）日：2015-05-21

  It is provided furin inhibitors and their uses for treating pathogen infection. Particularly, it is provided a method or use for the treatment of a pathogen infection, in a subject, comprising administering to the subject a therapeutically effective amount of the furin inhibitors or the composition disclosed, thereby preventing or treating pathogen infection, in the subject.

  本发明提供了抑制酶furin及其用于治疗病原体感染的方法。特别地，本发明提供了一种治疗主体的病原体感染的方法或用途，包括向该主体投予治疗有效量的furin抑制剂或所披露的组合物，从而预防或治疗该主体的病原体感染。
• STABLE PEPTIDE-BASED PACE4 INHIBITORS
  申请人：Day Robert

  公开号：US20140206622A1

  公开（公告）日：2014-07-24

  It is provided PACE4 inhibitors and their uses for treating infection, cancer. Particularly, it is provided a method or use for the treatment of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the PACE4 inhibitors or the composition disclosed.

  本文提供了PACE4抑制剂及其用于治疗感染和癌症的方法。特别地，本文提供了一种用于治疗患者癌症的方法或用途，包括向患者施用足够治疗量的PACE4抑制剂或所述的组合物。
• US9809621B2
  申请人：——

  公开号：US9809621B2

  公开（公告）日：2017-11-07
• Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill
  作者：Pierrick Nun、Charlotte Martin、Jean Martinez、Frédéric Lamaty

  DOI：10.1016/j.tet.2011.07.056

  日期：2011.10

  A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.