2-Methoxy-1-pyrrolidincarbonsaeure-phenylester | 69001-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-Methoxy-1-pyrrolidincarbonsaeure-phenylester
• 英文别名: 2-methoxy-pyrrolidine-1-carboxylic acid phenyl ester；Phenyl 2-methoxypyrrolidine-1-carboxylate
• CAS: 69001-14-5
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: JRMHDPZZHCRQIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Methoxy-1-pyrrolidincarbonsaeure-phenylester 在 氯化铵 作用下， 生成 1-(phenoxycarbonyl)-2-pyrroline
  参考文献：
  名称：

  Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines

  摘要：

  A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.

  DOI：

  10.3987/com-13-s(s)27
• 作为产物：
  描述：

  甲醇 、 1-吡咯烷羧酸苯酯 生成 2-Methoxy-1-pyrrolidincarbonsaeure-phenylester
  参考文献：
  名称：

  Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines

  摘要：

  A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.

  DOI：

  10.3987/com-13-s(s)27

文献信息

• US4234484A
  申请人：——

  公开号：US4234484A

  公开（公告）日：1980-11-18
• Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines
  作者：Osamu Onomura、Paul N. Gichuhi、Masami Kuriyama

  DOI：10.3987/com-13-s(s)27

  日期：——

  A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.