NsNHBr

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: NsNHBr
• 英文别名: N-bromo-4-nitrobenzenesulfonamide
• 化学式: C₆H₅BrN₂O₄S
• 分子量: 281.087
• InChiKey: AZBUNGAELDRRRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-硝基苯磺酰胺 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 氘代乙腈 为溶剂， 反应 12.0h， 生成 NsNHBr
  参考文献：
  名称：

  N-Bromosuccinimide Promoted One-Pot Synthesis of Guanidine: Scope and Mechanism

  摘要：

  A novel electrophilic one-pot guanidine synthesis has been developed using an olefin, a cyanimide, an amine, and N-bromosuccinimide. A number of guanidine derivatives were prepared with good to excellent yields. An rTRTVI precursor was also prepared based on this useful process.

  DOI：

  10.1021/ol202402y

文献信息

• <i>N</i>-Bromosuccinimide Promoted One-Pot Synthesis of Guanidine: Scope and Mechanism
  作者：Ling Zhou、Jie Chen、Jing Zhou、Ying-Yeung Yeung

  DOI：10.1021/ol202402y

  日期：2011.11.4

  A novel electrophilic one-pot guanidine synthesis has been developed using an olefin, a cyanimide, an amine, and N-bromosuccinimide. A number of guanidine derivatives were prepared with good to excellent yields. An rTRTVI precursor was also prepared based on this useful process.