N,N-Dimethyl-N'-(3-nitrophenyl)ethane-1,2-diamine | 758713-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-Dimethyl-N'-(3-nitrophenyl)ethane-1,2-diamine
• 英文别名: N',N'-dimethyl-N-(3-nitrophenyl)ethane-1,2-diamine
• CAS: 758713-72-3
• 化学式: C₁₀H₁₅N₃O₂
• 分子量: 209.248
• InChiKey: AYYKHVHGCTXXOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N-Dimethyl-N'-(3-nitrophenyl)ethane-1,2-diamine 生成 N-(2-Dimethylaminoethyl)benzene-1,3-diamine
  参考文献：
  名称：

  Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists

  摘要：

  本发明涉及尿苷II受体拮抗剂，含有它们的药物组合物以及它们的用途。

  公开号：

  US20050054850A1
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 2,4-dinitro-N-(3-nitrophenyl)benzenesulfonamide 、 4-三氟甲基苯甲酰氯 、 碘甲烷 生成 、 N,N-Dimethyl-N'-(3-nitrophenyl)ethane-1,2-diamine
  参考文献：
  名称：

  Solid-phase synthesis of tertiary-amino linked benzamides: a versatile method for forming C–N bonds with electron-rich and electron-poor anilines

  摘要：

  There currently are a wide variety of methods for forming C-N bonds on solid support. Two preferred methods are reductive aminations with resin bound amines or aldehydes as well as standard alkylation strategies. We herein disclose the scope and application of the Mitsunobu reaction of 2,4-dinitro-N-phenylbenzenesulfonamides derived from both electron-rich and electron-poor anilines as a practical and versatile addition to the repertoire of solid phase C-N bond forming reactions. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.192

文献信息

• Solid-phase synthesis of tertiary-amino linked benzamides: a versatile method for forming C–N bonds with electron-rich and electron-poor anilines
  作者：Kevin W. Gillman、Danielle Bocchino、Jeffrey W. Noonan、Milind Deshpande、Weixu Zhai

  DOI：10.1016/j.tetlet.2007.07.192

  日期：2007.10

  There currently are a wide variety of methods for forming C-N bonds on solid support. Two preferred methods are reductive aminations with resin bound amines or aldehydes as well as standard alkylation strategies. We herein disclose the scope and application of the Mitsunobu reaction of 2,4-dinitro-N-phenylbenzenesulfonamides derived from both electron-rich and electron-poor anilines as a practical and versatile addition to the repertoire of solid phase C-N bond forming reactions. (C) 2007 Elsevier Ltd. All rights reserved.
• PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS.
  申请人：ENCYSIVE PHARMACEUTICALS INC.

  公开号：EP1603884A2

  公开（公告）日：2005-12-14
• EP1603884A4
  申请人：——

  公开号：EP1603884A4

  公开（公告）日：2008-05-28
• US7265122B2
  申请人：——

  公开号：US7265122B2

  公开（公告）日：2007-09-04
• US7320989B2
  申请人：——

  公开号：US7320989B2

  公开（公告）日：2008-01-22