2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile | 711020-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile
• CAS: 711020-24-5
• 化学式: C₂₃H₁₆Cl₂N₂O₃
• 分子量: 439.298
• InChiKey: BVSCAUUQUUOPJC-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.18
• 重原子数：
  30.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  70.4
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-[(S)-2-methylsulfinylphenyl]piperidine 、 2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 以94%的产率得到2-((2S)-2-(3,4-dichlorophenyl)-4-{4-[(S)-2-(methylsulfinyl)phenyl]piperidin-1-yl}butyl)-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile
  参考文献：
  名称：

  Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

  摘要：

  Previously we reported on the synthesis and properties of a series of highly potent piperidinyl 2-subsituted-3-cyano-1-naphthamide NK1 antagonists that includes 3 and 4. Here we report our efforts to alleviate a troublesome atropisomeric property of those derivatives by introduction of a tethering bridge that, in addition, could be used to lock the resulting cyclic derivatives in a purported NK1 pharmacophore conformation. Using 3 as a starting point, the naphtho[2, 1-b][1,5]oxazocine, 17, was found to contain the optimal ring tether size (8) for retaining NK1 activity, was more NK1 versus NK2 selective, and reduced the number of atropisomers from four to two. Cyclic derivatives 29 and 32, which exist as essentially single atropisomers in the purported pharmacophore conformation. were prepared in the closely related naphtho[1,2-f][1,4]oxazocine series as part of an effort to use mono methyl substitution of the tethering bridge as a conformation stabilizing factor. Both 29 and 32 were found to be less active as NK1 antogonists than the non-methylated parent 28 possibly due to methyl group destabilization of receptor interaction. We discuss the above findings in the context of a previously proposed NK1 pharmacophore model and present a further refinement of that model. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.015
• 作为产物：
  描述：

  3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-hydroxy-1-naphthamide 在 sodium hydroxide 、 草酰氯 、 硫酸 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 、 水 为溶剂， 反应 5.25h， 生成 2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile
  参考文献：
  名称：

  Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

  摘要：

  Previously we reported on the synthesis and properties of a series of highly potent piperidinyl 2-subsituted-3-cyano-1-naphthamide NK1 antagonists that includes 3 and 4. Here we report our efforts to alleviate a troublesome atropisomeric property of those derivatives by introduction of a tethering bridge that, in addition, could be used to lock the resulting cyclic derivatives in a purported NK1 pharmacophore conformation. Using 3 as a starting point, the naphtho[2, 1-b][1,5]oxazocine, 17, was found to contain the optimal ring tether size (8) for retaining NK1 activity, was more NK1 versus NK2 selective, and reduced the number of atropisomers from four to two. Cyclic derivatives 29 and 32, which exist as essentially single atropisomers in the purported pharmacophore conformation. were prepared in the closely related naphtho[1,2-f][1,4]oxazocine series as part of an effort to use mono methyl substitution of the tethering bridge as a conformation stabilizing factor. Both 29 and 32 were found to be less active as NK1 antogonists than the non-methylated parent 28 possibly due to methyl group destabilization of receptor interaction. We discuss the above findings in the context of a previously proposed NK1 pharmacophore model and present a further refinement of that model. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.015