2-methyl-4-(methylthio)thiophene | 943867-44-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-methyl-4-(methylthio)thiophene
• 英文别名: 2-Methyl-4-methylsulfanylthiophene
• CAS: 943867-44-5
• 化学式: C₆H₈S₂
• 分子量: 144.262
• InChiKey: BUPDJQYKQYXYBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲硫基噻吩 、 碘甲烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 以67%的产率得到2-methyl-3-(methylthio)thiophene
  参考文献：
  名称：

  金属化反应。XXXVI。（甲硫基）-和（甲磺酰基）噻吩金属化的研究

  摘要：

  甲硫基和甲基磺酰基噻吩可通过正丁基锂和超碱（LICKOR）一步一步进行多金属化。2-（甲硫基）噻吩在5中和在α与甲硫基硫原子上被双金属双金属化。3-（甲硫基）噻吩被有机锂在2和5位上双金属化，并在这两个位置被三金属化，并通过超碱在硫醚醚硫原子的α处被三金属化。3-（甲基磺酰基）噻吩通过有机锂在2中和在磺酰基硫原子的α中被双金属化，而2-（甲基磺酰基）噻吩在相同条件下进行降解。

  DOI：

  10.1002/jhet.5570440316

文献信息

• AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150005348A1

  公开（公告）日：2015-01-01

  An amide compound represented by formula (I) has an excellent pest control effect. (In the formula, Y represents a 3-7 membered saturated heterocyclic ring which contains, as ring-forming components(s), one or more atoms or groups that are selected from the group consisting of an oxygen atom and —S(O) t —, the saturated heterocyclic ring may have one to three atoms or groups selected from group D and t represents 0 or the like; x represents a C 1 -C 8 chain hydrocarbon group having one group that is selected from group A; W represents —CR 8 — or the like; r represents 1 or the like; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 may be the same or different and each represents a hydrogen atom or the like; and n represents 1 or the like.)

  式(I)所代表的酰胺化合物具有出色的杀虫效果。（在该式中，Y代表一个含有3-7个饱和杂环环的结构，该结构中包含一个或多个从氧原子和-S(O)t-组成的原子或基团，饱和杂环环可能有一个到三个从D组成的原子或基团，t代表0或类似物；x代表一个C1-C8链烃基，其中有一个来自A组的基团；W代表-CR8-或类似物；r代表1或类似物；R1、R2、R3、R4、R5、R6、R7和R8可以相同也可以不同，每个代表一个氢原子或类似物；n代表1或类似物。）
• METHOD FOR CONTROLLING ARTHROPOD PEST
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150344466A1

  公开（公告）日：2015-12-03

  An amide compound represented by formula (I): [wherein A represents a 3- to 7-membered saturated heterocyclic ring which contains, as ring-forming component(s), one or more atoms or groups selected from the group consisting of an oxygen atom and —S(O) t —, t represents 0, etc., R 1 and R 2 are the same or different and represent a hydrogen atom, etc., n represents 0, etc., the following formula (II): represents a 5-membered aromatic ring, in which Z represents a nitrogen atom or a carbon atom and X 1 , X 2 and X 3 are the same or different and represent a nitrogen atom, etc., R 3 and R 4 are the same or different and represent a hydrogen atom, etc., m represents 0 to 2, Q represents one group selected from group A or a C1 to C8 chain hydrocarbon group optionally having one group selected from group A, Y represents an oxygen atom, etc., u represents 0, etc., and v represents 0, etc.] has excellent arthropod pest controlling effects.

  化合物式(I)所代表的酰胺化合物：[其中A代表一个3到7个成员的饱和杂环环，该环包含作为环构成组分之一或多个原子或基团，所选自氧原子和—S（O）t—群，t代表0等；R1和R2相同或不同，代表氢原子等；n代表0等；下列式子(II)代表一个5个成员的芳香环，在该环中Z代表一个氮原子或一个碳原子，X1、X2和X3相同或不同，代表氮原子等，R3和R4相同或不同，代表氢原子等，m代表0到2，Q代表从群A中选择的一个群或一个C1到C8链烃基团，该基团可以选择从群A中选择的一个群，Y代表氧原子等，u代表0等，v代表0等]具有优良的节肢动物害虫控制效果。
• Amide compound, an arthropod pest control agent and a method for controlling arthropod pest
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2952096B1

  公开（公告）日：2018-04-04
• US9814235B2
  申请人：——

  公开号：US9814235B2

  公开（公告）日：2017-11-14
• Metallation reactions. XXXVI. A study on the metallation of (methylthio)- and (methylsulfonyl)thiophenes
  作者：Claudia Fattuoni、Michele Usai、Maria G. Cabiddu、Enzo Cadoni、Stefania De Montis、Francesca Sotgiu、Salvatore Cabiddu

  DOI：10.1002/jhet.5570440316

  日期：2007.5

  Methylthio- and methylsulfonyl thiophenes were polymetallated by n-buthyllithium and superbase (LICKOR) in one-step. 2-(Methylthio)thiophene was bimetallated in 5 and in alpha to the methylthio sulfur atom by superbase. 3-(Methylthio)thiophene was bimetallated in both 2 and 5 positions by the organolithium and trimetallated in these two positions and in alpha to the thioethereal sulfur atom by superbase

  甲硫基和甲基磺酰基噻吩可通过正丁基锂和超碱（LICKOR）一步一步进行多金属化。2-（甲硫基）噻吩在5中和在α与甲硫基硫原子上被双金属双金属化。3-（甲硫基）噻吩被有机锂在2和5位上双金属化，并在这两个位置被三金属化，并通过超碱在硫醚醚硫原子的α处被三金属化。3-（甲基磺酰基）噻吩通过有机锂在2中和在磺酰基硫原子的α中被双金属化，而2-（甲基磺酰基）噻吩在相同条件下进行降解。