O,O-Dimethyl-sec-butyl-phosphonat | 59259-31-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: O,O-Dimethyl-sec-butyl-phosphonat
• 英文别名: Dimethyl 2-butylphosphonat；Dimethyl butan-2-ylphosphonate；2-dimethoxyphosphorylbutane
• CAS: 59259-31-3
• 化学式: C₆H₁₅O₃P
• 分子量: 166.157
• InChiKey: LDSHYZILDAPFEP-UHFFFAOYSA-N

物化性质

• 沸点：
  199.8±9.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O,O-Dimethyl-sec-butyl-phosphonat 在 /BRN= 956566/ 作用下， 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Jentzsch,R. et al., Journal fur praktische Chemie (Leipzig 1954), 1975, vol. 317, p. 733 - 744

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl (2-(2-tosylhydrazinyl)butan-2-yl)phosphonate 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 生成 O,O-Dimethyl-sec-butyl-phosphonat
  参考文献：
  名称：

  A New Route tosec-Alkanephosphonates

  摘要：

  DOI：

  10.1055/s-1977-24311

文献信息

• Promotion of Dehydrazination by Nitrobenzenesulfonyl Group from Phosphorus-hydrazone Adducts
  作者：Mitsuji Yamashita、Jun Takeuchi、Kaname Nakatani、Tatsuo Oshikawa、Saburo Inokawa

  DOI：10.1246/bcsj.58.377

  日期：1985.1

  Dehydrazination of adducts of phenylsulfonylhydrazones and phosphorus compounds was promoted by a nitro substituent on the ring to afford derivatives of a phosphine oxide and phosphonates.

  苯磺酰肼与磷化合物的加成物的脱水促反应在环上的硝基取代基的促进下，生成了磷烯氧化物和磷酸酯的衍生物。
• The catalytic aerobic synthesis of quaternary α-hydroxy phosphonates via direct hydroxylation of phosphonate compounds
  作者：Lijun Gu、Cheng Jin、Hongtao Zhang

  DOI：10.1039/c4nj02072c

  日期：——

  A highly efficient Cu-catalyzed direct hydroxylation of phosphonate compounds has been developed. This transformation provides a powerful method for the synthesis of quaternary α-hydroxy phosphonates in good yields. The direct transformation process, regiospecific selectivity, and good tolerance to a variety of substituents make it an alternative approach to the reported protocols.

  已经开发了高效的铜催化的膦酸酯化合物的直接羟基化。该转化为以高收率合成α-羟基膦酸酯季盐提供了一种有力的方法。直接转化过程，区域特异性选择性以及对各种取代基的良好耐受性使其成为所报道方案的替代方法。
• Synthesis of Quaternary<i>α</i>-Hydroxy Phosphonates<i>via</i>Direct Hydroxylation of Phosphonate Compounds
  作者：Jiyan Liu、Wei Wang、Rui Wang、Lijun Gu

  DOI：10.1002/cjoc.201400858

  日期：2015.5

  It was found for the first time that Cs2CO3 serves as highly efficient catalyst for the direct hydroxylation reactions of phosphonates under mild conditions. This reaction provides an efficient approach to quaternary α‐hydroxy phosphonates, which possess intriguing biological activities and are widely used in many areas.

  首次发现在温和条件下，Cs 2 CO 3可以用作膦酸酯直接羟基化反应的高效催化剂。该反应提供了一种有效的方法来处理季铵化的α-羟基膦酸酯，其具有令人着迷的生物学活性，并在许多领域得到了广泛的应用。
• COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
  申请人：Hoveyda Hamid

  公开号：US20110230477A1

  公开（公告）日：2011-09-22

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

  本发明涉及式（I）的新化合物及其在治疗代谢性疾病方面的应用。
• C–H Hydroxylation of Phosphonates with Oxygen in [bmIm]OH To Produce Quaternary α-Hydroxy Phosphonates
  作者：Xiangguang Li、Cheng Jin、Lijun Gu

  DOI：10.1021/jo502883q

  日期：2015.2.20

  A highly efficient and mild [bmIm]OH-catalyzed a-hydroxylation of phosphonates using O-2 as the oxygen source is described. The employment of ionic liquid under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of quaternary a-hydroxy phosphonates.