N-(2-溴-1-苯基乙基)乙酰胺 | 74357-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-溴-1-苯基乙基)乙酰胺
• 英文名称: N-(2-bromo-1-phenylethyl)acetamide
• 英文别名: N-(2-Brom-1-phenyl-aethyl)-acetamid
• CAS: 74357-14-5
• 化学式: C₁₀H₁₂BrNO
• 分子量: 242.115
• InChiKey: GOOHKLRABXRQKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴-1-苯乙醇 、 乙腈 在 硫酸 作用下， 生成 N-(2-溴-1-苯基乙基)乙酰胺
  参考文献：
  名称：

  A New Reaction of Nitriles. V. Preparation of N-(2-Halo-1-ethyl)-amides¹

  摘要：

  DOI：

  10.1021/ja01168a060

文献信息

• Selective aerobic oxidative dibromination of alkenes with aqueous HBr and sodium nitrite as a catalyst
  作者：Ajda Podgoršek、Marco Eissen、Jens Fleckenstein、Stojan Stavber、Marko Zupan、Jernej Iskra

  DOI：10.1039/b814989e

  日期：——

  Various alkenes (internal, terminal, aryl and alkyl substituted) and 1,2-diphenylethyne were efficiently and selectively dibrominated using 2 equivalents of 48% aqueous hydrobromic acid, with air as an oxidant and sodium nitrite as a catalyst. Despite the presence of water, only trans dibromination occurred producing anti-1,2-dibromoalkanes and (E)-1,2-dibromo-1,2-diphenylethene. A comparison of resource

  各种各样的 烯烃 （内部，终端， 芳基 和 烷基 取代）和 1,2-二苯乙炔 使用2当量的48％水溶液有效地和选择性地溴化了二溴 氢溴酸，以空气为氧化剂， 亚硝酸钠 作为一个 催化剂。尽管存在水，仅发生反式二溴化反应，生成抗-1,2-二溴代烷烃，（E）-1,2-二溴-1,2-二苯乙烯。NaNO 2催化好氧的资源需求，废物产生与环境，健康和安全问题的比较溴化 具有分子溴和其他氧化性 溴化 方法表明，该方法不仅具有选择性和有效性，而且具有较好的环境特征。
• Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form
  申请人：H. Lundbeck A/S

  公开号：US20030138847A1

  公开（公告）日：2003-07-24

  A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional gropusgroups is compressed into tablets after pre-treatment with an aprotic organic solvent groups are compressed into tablets after pre-treatment with an aprotic organic solvent.

  一种在溶剂介质中用于有机化学合成的聚合物支撑剂的给药形式，由固定重量的含有官能团的聚合物珠子组成，该聚合物不溶于预定合成的溶剂中，其形式为重量和成分基本相同的压缩片剂，其中聚合物珠子基本完好无损，当片剂在所述溶剂中崩解时就会释放出来。 在传统合成、并行合成、分拆混合合成和/或组合化学中均可使用这种配料形式。 在生产定量给药形式的方法中，具有官能团的聚合物珠子在用壬烷有机溶剂预处理后被压缩成片剂。
• InX3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo- and α-fluoroamides
  作者：J.S. Yadav、B.V. Subba Reddy、D. Narasimha Chary、D. Chandrakanth

  DOI：10.1016/j.tetlet.2008.12.090

  日期：2009.3

  A variety of alkenes are converted into the corresponding alpha-fluoroamides in high yields by selectfluor (TM) in the presence of 10 mol % of InF3 in nitrile solution. alpha-Bromoamides are obtained with NBS in the presence of 10 mol % InBr3 under similar conditions. The use of Lewis acid in haloamidation significantly improved the yields and reaction rates. (C) 2009 Elsevier Ltd. All rights reserved.
• Reihlen; Knoepfle; Sapper, Justus Liebigs Annalen der Chemie, 1938, vol. 534, p. 248
  作者：Reihlen、Knoepfle、Sapper

  DOI：——

  日期：——
• DOSING FORM FOR A POLYMER SUPPORT, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND METHOD FOR PRODUCTION OF SAID DOSING FORM
  申请人：H. Lundbeck A/S

  公开号：EP1268050A2

  公开（公告）日：2003-01-02