1-difluoromethyl-7-iodo-1-methyl-1,2,3,4-tetrahydro-benzofuro[2,3-C]pyridine | 1315688-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-difluoromethyl-7-iodo-1-methyl-1,2,3,4-tetrahydro-benzofuro[2,3-C]pyridine
• 英文别名: 1-(difluoromethyl)-7-iodo-1-methyl-3,4-dihydro-2H-[1]benzofuro[2,3-c]pyridine
• CAS: 1315688-60-8
• 化学式: C₁₃H₁₂F₂INO
• 分子量: 363.146
• InChiKey: REVXRYKBMUKQCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-difluoromethyl-7-iodo-1-methyl-1,2,3,4-tetrahydro-benzofuro[2,3-C]pyridine 在 copper(l) iodide 、 新铜试剂 、 sodium t-butanolate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 生成 1-(difluoromethyl)-7-(3-fluorophenyl)sulfonyl-1-methyl-3,4-dihydro-2H-[1]benzofuro[2,3-c]pyridine
  参考文献：
  名称：

  Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists

  摘要：

  7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with reduced hERG liability. An advanced analog tested in rat social recognition model showed significant activity suggesting potential utility in the enhancement of short-term memory. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.050
• 作为产物：
  描述：

  在 硼烷四氢呋喃络合物 、 三氟乙酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 35.0h， 生成 1-difluoromethyl-7-iodo-1-methyl-1,2,3,4-tetrahydro-benzofuro[2,3-C]pyridine
  参考文献：
  名称：

  Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists

  摘要：

  7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with reduced hERG liability. An advanced analog tested in rat social recognition model showed significant activity suggesting potential utility in the enhancement of short-term memory. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.050

文献信息

• Tricyclic Derivatives and Their Pharmaceutical Use and Compositions
  申请人：Bacon Edward R.

  公开号：US20120295882A1

  公开（公告）日：2012-11-22

  This application relates to tricyclic compounds of Formula I: including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula I and uses therefore.

  本申请涉及公式I的三环化合物，包括所有立体异构体、立体异构体混合物和其盐。本申请还涉及包含公式I化合物的组合物及其用途。
• Tricyclic derivatives and their pharmaceutical use and compositions
  申请人：Bacon Edward R.

  公开号：US08765779B2

  公开（公告）日：2014-07-01

  This application relates to tricyclic compounds of Formula I: including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula I and uses therefore.

  该申请涉及公式I的三环化合物，包括所有立体异构体、立体异构体混合物和其盐。该申请还涉及包含公式I化合物的组合物以及其用途。
• TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
  申请人：Cephalon, Inc.

  公开号：EP2516445A2

  公开（公告）日：2012-10-31
• US8765779B2
  申请人：——

  公开号：US8765779B2

  公开（公告）日：2014-07-01
• [EN] TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS<br/>[FR] DÉRIVÉS TRICYCLIQUES ET LEUR UTILISATION PHARMACEUTIQUE ET COMPOSITIONS
  申请人：CEPHALON INC

  公开号：WO2011087712A2

  公开（公告）日：2011-07-21

  This application relates to tricyclic compounds of Formula (I), including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula (I) and uses therefore.