甲碘布着 | 15351-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲碘布着
• 中文别名: 甲碘布卓
• 英文名称: 1-(3-carbamoyl-3,3-diphenyl-propyl)-1-methyl-hexahydro-azepinium; iodide
• 英文别名: 1-(3-Carbamoyl-3,3-diphenyl-propyl)-1-methyl-hexahydro-azepinium; Jodid；4-(1-Methylazepan-1-ium-1-yl)-2,2-diphenylbutanimidate--hydrogen iodide (1/1)；4-(1-methylazepan-1-ium-1-yl)-2,2-diphenylbutanimidate;hydroiodide
• CAS: 15351-05-0
• 化学式: C₂₃H₃₁N₂O*I
• 分子量: 478.416
• InChiKey: HMFBCJNMIYZRKQ-UHFFFAOYSA-N

物化性质

• 熔点：
  212-213 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.434
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

制备方法与用途

类别：有毒物质

毒性分级：中毒

急性毒性：

• 口服-大鼠 LD50: 2800 毫克/公斤
• 口服-小鼠 LD50: 820 毫克/公斤

可燃性危险特性：热分解排出有毒氮氧化物和碘化物烟雾

储运特性：库房通风、低温干燥

灭火剂：水、二氧化碳、泡沫、干粉

反应信息

• 作为产物：
  描述：

  环己亚胺 在 硫酸 、 xylene 作用下， 生成 甲碘布着
  参考文献：
  名称：

  alpha-alpha-diphenyl-gamma-hexamethyleneiminobutyramide

  摘要：

  公开号：

  US02881165A1

文献信息

• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• A BASE FORMING DRUG-LAYERED SILICATE HYBRID CONTAINING BASIC POLYMER AND ITS SYNTHESIS METHOD
  申请人：Nanohybrid Co., Ltd.

  公开号：EP1986693A1

  公开（公告）日：2008-11-05
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Base Forming Drug-Layered Silicate Hybrid Containing Basic Polymer and its Synthesis Method
  申请人：Choy Jin-Ho

  公开号：US20080119519A1

  公开（公告）日：2008-05-22

  Provided are a hybrid of a poorly soluble basic drug and a layered silicate, including a water-soluble basic polymer, and a method of preparing the same. The water-soluble basic polymer may be an aminoalkylmethacrylate copolymer (e.g., Eudragit E 100: a copolymer composed of 1:2:1 ratio of butyl methacrylate, (2,2-dimethylaminoethyl)methacrylate, and methyl methacrylate, Degussa) or polyvinylacetal diethylaminoacetate (AEA). In an oral formulation including the hybrid, a short-term dissolution of the poorly soluble drug can be increased to 90%, thereby increasing drug bioavailability.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.