(S)-5-Azidomethyl-3-{3,5-difluoro-4-[4-oxo-3-(tetrahydro-pyran-2-yloxymethyl)-imidazolidin-1-yl]-phenyl}-oxazolidin-2-one | 693787-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (S)-5-Azidomethyl-3-{3,5-difluoro-4-[4-oxo-3-(tetrahydro-pyran-2-yloxymethyl)-imidazolidin-1-yl]-phenyl}-oxazolidin-2-one
• 英文别名: 5-(Azidomethyl)-3-[3,5-difluoro-4-[3-(oxan-2-yloxymethyl)-4-oxoimidazolidin-1-yl]phenyl]-1,3-oxazolidin-2-one
• CAS: 693787-17-6
• 化学式: C₁₉H₂₂F₂N₆O₅
• 分子量: 452.418
• InChiKey: SEVLQPJRJSJXHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  85.9
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (S)-5-Azidomethyl-3-{3,5-difluoro-4-[4-oxo-3-(tetrahydro-pyran-2-yloxymethyl)-imidazolidin-1-yl]-phenyl}-oxazolidin-2-one 、 4-甲基苯磺酸吡啶 以 乙醇 为溶剂， 以86%的产率得到(S)-5-Azidomethyl-3-[3,5-difluoro-4-(3-hydroxymethyl-4-oxo-imidazolidin-1-yl)-phenyl]-oxazolidin-2-one
  参考文献：
  名称：

  Novel heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及新型噁唑啉酮化合物(I)、它们的立体异构体、它们的盐以及含有它们的药物组合物。此外，本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及药物组合物的方法。

  公开号：

  US20040102494A1
• 作为产物：
  描述：

  (S)-3-{3,5-Difluoro-4-[4-oxo-3-(tetrahydro-pyran-2-yloxymethyl)-imidazolidin-1-yl]-phenyl}-5-hydroxymethyl-oxazolidin-2-one 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-5-Azidomethyl-3-{3,5-difluoro-4-[4-oxo-3-(tetrahydro-pyran-2-yloxymethyl)-imidazolidin-1-yl]-phenyl}-oxazolidin-2-one
  参考文献：
  名称：

  Novel heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及新型噁唑啉酮化合物(I)、它们的立体异构体、它们的盐以及含有它们的药物组合物。此外，本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及药物组合物的方法。

  公开号：

  US20040102494A1

文献信息

• Intermediates of novel heterocyclic compounds having antibacterial activity and process for their preparation
  申请人：Selvakumar Natesan

  公开号：US20060293315A1

  公开（公告）日：2006-12-28

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及式(I)的新型噁唑啉化合物，它们的立体异构体，它们的盐和含有它们的药物组成物。本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐和药物组成物的方法。
• Salts of novel heterocyclic compounds having antibacterial activity
  申请人：Selvakumar Natesan

  公开号：US20070004712A1

  公开（公告）日：2007-01-04

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及公式（I）的新型噁唑啉酮化合物、它们的立体异构体、它们的盐以及含有它们的制药组合物。本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及制药组合物的方法。
• US7160912B2
  申请人：——

  公开号：US7160912B2

  公开（公告）日：2007-01-09
• Novel heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US20040102494A1

  公开（公告）日：2004-05-27

  The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. 1 The present invention also relates to a process for the preparation of the above said novel compounds, their stereoisomers, their salts and pharmaceutical compositions.

  本发明涉及新型噁唑啉酮化合物(I)、它们的立体异构体、它们的盐以及含有它们的药物组合物。此外，本发明还涉及一种制备上述新型化合物、它们的立体异构体、它们的盐以及药物组合物的方法。