(3S,4S)-tert-butyl 3-[2'-(benzyloxy)ethyl]-5-nitro-2-oxo-4-phenylpentanoate | 1245908-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4S)-tert-butyl 3-[2'-(benzyloxy)ethyl]-5-nitro-2-oxo-4-phenylpentanoate
• CAS: 1245908-02-4
• 化学式: C₂₄H₂₉NO₆
• 分子量: 427.497
• InChiKey: NDZGUJPBCHVFNK-LEWJYISDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  31.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  95.74
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  反式硝基苯乙烯 、 tert-butyl 5-(benzyloxy)-2-oxopentanoate 在 C₃₈H₆₂N₂*Cl^(1-)*Cu⁽²⁺⁾*HO^(1-) 作用下， 以 异丙醇 为溶剂， 反应 8.0h， 生成 tert-butyl 3-[2'-(benzyloxy)ethyl]-5-nitro-2-oxo-4-phenylpentanoate 、 (3S,4S)-tert-butyl 3-[2'-(benzyloxy)ethyl]-5-nitro-2-oxo-4-phenylpentanoate
  参考文献：
  名称：

  Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes

  摘要：

  As a part of our research project on hard anion-late transition metal complexes as mild acid-base catalysts, we describe herein that Cu-II hydroxo complexes having chiral N-substituted-diaminocyclohexanes are mild and selective catalysts, which are applicable to the catalytic asymmetric conjugate addition of alpha-keto esters to nitroolefins. The reaction proceeded diastereoselectively without the detectable formation of self-aldol products, affording the corresponding coupling products with anti-stereochemistry in an enantioselective manner. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.009