(Z)-2-bromo-1-(1-(3-fluoro-4-methoxyphenyl)-2-(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-3,4,5-trimethoxybenzene | 1246764-45-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-2-bromo-1-(1-(3-fluoro-4-methoxyphenyl)-2-(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-3,4,5-trimethoxybenzene
• 英文别名: 2-bromo-1-[(Z)-1-(3-fluoro-4-methoxyphenyl)-2-[4-methoxy-3-(methoxymethoxy)phenyl]ethenyl]-3,4,5-trimethoxybenzene
• CAS: 1246764-45-3
• 化学式: C₂₇H₂₈BrFO₇
• 分子量: 563.418
• InChiKey: YOMGUAMDXSTSBJ-WQRHYEAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (Z)-2-bromo-1-(1-(3-fluoro-4-methoxyphenyl)-2-(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-3,4,5-trimethoxybenzene 在 正丁基锂 、 盐酸 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以53%的产率得到(E)-5-(2-(3-fluoro-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
  参考文献：
  名称：

  Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

  摘要：

  A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.007
• 作为产物：
  描述：

  (E)-2-bromo-1-(1-iodo-2-(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-3,4,5-trimethoxybenzene 、 2-氟-4-碘-1-甲氧基苯 在 zinc(II) chloride 、 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 四氢呋喃 为溶剂， 以50%的产率得到(Z)-2-bromo-1-(1-(3-fluoro-4-methoxyphenyl)-2-(4-methoxy-3-(methoxymethoxy)phenyl)vinyl)-3,4,5-trimethoxybenzene
  参考文献：
  名称：

  Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

  摘要：

  A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.007

文献信息

• Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4
  作者：Evelia Rasolofonjatovo、Olivier Provot、Abdallah Hamze、Jérome Bignon、Sylviane Thoret、Jean-Daniel Brion、Mouâd Alami

  DOI：10.1016/j.ejmech.2010.05.007

  日期：2010.9

  A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.