3-(4-hydroxy-3,5-dimethoxyphenyl)-2-methylpropanal | 1352129-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(4-hydroxy-3,5-dimethoxyphenyl)-2-methylpropanal
• CAS: 1352129-31-7
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: HTTQXQJKGGENDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  一氧化碳 、 4-烯丙基-2,6-二甲氧基苯酚 在 acetylacetonatodicarbonylrhodium(l) 、 磷酸 、 氢气 、 抗氧化剂 THP-24 、 苯甲醚 作用下， 以 二氯甲烷 为溶剂， 110.0 ℃ 、2.07 MPa 条件下， 反应 2.0h， 以70%的产率得到1,3-Dimethoxy-5,6-dihydronaphthalen-2-ol
  参考文献：
  名称：

  Rhodium-catalyzed one-pot hydroformylation–cyclization of allylbenzene derivatives: Simple and efficient route to 5,6-dihydronaphthalenes

  摘要：

  The one-pot hydroformylation-cyclization of allylbenzene derivatives by the catalyst system Rh(CO)(2)a-cac/ultranox626/CO/H(2)/CH(2)Cl(2) led chemoselectively to 5,6-dihydronaphthalene derivatives 5a-d in good yields. The addition of a catalytic amount of H(3)PO(4) enhanced in situ the cyclization process via the nucleophilic attack on the carbonyl group of the linear aldehyde, and finally the elimination of alcohol. The type of substitution on phenyl group of the allylbenzene is of great importance in enhancing the cyclization process. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2010.02.014

文献信息

• Thermoregulated Microemulsions by Cyclodextrin Sequestration: A New Approach to Efficient Catalyst Recovery
  作者：Loïc Leclercq、Matthieu Lacour、Samantha H. Sanon、Andreea R. Schmitzer

  DOI：10.1002/chem.200900763

  日期：2009.6.22

  The combination of imidazolium surfactants with α‐cyclodextrins (CDs, in green) was used as a control element in the thermoregulated aqueous olefin hydroformylation. The self‐assembly of the imidazolium surfactants (red) favors the micellization process at high temperatures, whereas at lower temperatures the complexation of the surfactant monomers into the α‐CDs is favored.

  咪唑鎓表面活性剂与α-环糊精（CD，绿色）的组合用作温度调节烯烃加氢甲酰化反应中的控制元素。咪唑类表面活性剂（红色）的自组装有利于高温下的胶束化过程，而在较低温度下，表面活性剂单体向α-CDs的络合是有利的。
• Rhodium-catalyzed one-pot hydroformylation–cyclization of allylbenzene derivatives: Simple and efficient route to 5,6-dihydronaphthalenes
  作者：Mouheddin Alhaffar、Rami Suleiman、Bassam El Ali

  DOI：10.1016/j.catcom.2010.02.014

  日期：2010.3

  The one-pot hydroformylation-cyclization of allylbenzene derivatives by the catalyst system Rh(CO)(2)a-cac/ultranox626/CO/H(2)/CH(2)Cl(2) led chemoselectively to 5,6-dihydronaphthalene derivatives 5a-d in good yields. The addition of a catalytic amount of H(3)PO(4) enhanced in situ the cyclization process via the nucleophilic attack on the carbonyl group of the linear aldehyde, and finally the elimination of alcohol. The type of substitution on phenyl group of the allylbenzene is of great importance in enhancing the cyclization process. (C) 2010 Elsevier B.V. All rights reserved.