2-氟-N4,N4-二甲基-1,4-苯二胺 | 334905-81-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氟-N4,N4-二甲基-1,4-苯二胺
• 英文名称: 2-Fluoro-N⁴,N⁴-dimethyl-benzene-1,4-diamine
• 英文别名: 3-Fluoro-N1,N1-dimethylbenzene-1,4-diamine；2-fluoro-4-N,4-N-dimethylbenzene-1,4-diamine
• CAS: 334905-81-6
• 化学式: C₈H₁₁FN₂
• mdl: MFCD18806046
• 分子量: 154.187
• InChiKey: VOBMVVCRSLQHGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氟-N4,N4-二甲基-1,4-苯二胺 在 盐酸 、 sodium sulfide 、 iron(III) chloride 作用下， 以 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  WO2008/124550

  摘要：

  公开号：
• 作为产物：
  描述：

  2,4-二氟硝基苯 在 palladium on activated charcoal 氢气 作用下， 生成 2-氟-N4,N4-二甲基-1,4-苯二胺
  参考文献：
  名称：

  Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

  摘要：

  We have further explored the structure-activity relationships of pyrido[1,2-a]benzimidazole (PBI) derivatives (viz. prototype 1), a novel series of central GABA-A receptor modulators, with the intent of enhancing oral efficacy. A study involving the introduction of acidic or basic groups led to the identification of RWJ-38293 (3a) as a potential anxiolytic agent.

  DOI：

  10.1016/0960-894x(96)00025-x

文献信息

• Van Beek,L.K.H. et al., Recueil des Travaux Chimiques des Pays-Bas, 1968, vol. 87, p. 737 - 745
  作者：Van Beek,L.K.H. et al.

  DOI：——

  日期：——
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE BRAIN DISEASE COMPRISING MULTI-TARGETING COMPOUNDS
  申请人：UNIST Academy-Industry Research Corporation

  公开号：US20160243059A1

  公开（公告）日：2016-08-25

  A pharmaceutical composition for treating or preventing a degenerative brain disease, the pharmaceutical composition including, as an active component, a multi-targeting compound for further improving treatment efficiency of a degenerative brain disease such as Alzheimer's disease is disclosed. The pharmaceutical composition includes a compound represented by Formula 1 or 2, wherein the compound of Formula 1 or 2 induces a gathering of amyloid-peptides in a manner of toxicity-free aggregation under conditions both in the presence and absence of metals such as copper and zinc, and also reacts with multiple targets of Alzheimer's diseases at once to inhibit toxicity thereof, the multiple targets including amyloid-peptide, metal-amyloid-peptide, a metal, and an activated oxidizing species. The pharmaceutical composition including the compound of Formula 1 or 2 may be utilized as a therapeutic agent or a health food in regard to a brain disease, including Alzheimer's disease.
• US6316605B1
  申请人：——

  公开号：US6316605B1

  公开（公告）日：2001-11-13
• [EN] PHENOTHIAZIN DERIVATIVES FOR ANTIVIRAL TREATMENTS<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE CONÇUS POUR DES TRAITEMENTS ANTIVIRAUX
  申请人：PROSETTA CORP

  公开号：WO2008124550A1

  公开（公告）日：2008-10-16

  [EN] Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
  [FR] L'invention propose des composés et des méthodes de prévention et de traitement d'infections virales. Dans certains modes de réalisation, de nouveaux composés à activité antivirale à large spectre sont proposés. Dans des modes de réalisation plus spécifiques, les composés et les procédés sont efficaces contre des virus tels que l'encéphalite équine du Venezuela, le virus du Nil occidental et l'hépatite C.
• WO2008/124550
  申请人：——

  公开号：——

  公开（公告）日：——