2-([2,2';5',2'']Terthiophen-5-ylmethoxy)-tetrahydro-pyran | 218764-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 2-([2,2';5',2'']Terthiophen-5-ylmethoxy)-tetrahydro-pyran
• CAS: 218764-88-6
• 化学式: C₁₈H₁₈O₂S₃
• 分子量: 362.538
• InChiKey: HDQGDOKTQRVGOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.25
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-([2,2';5',2'']Terthiophen-5-ylmethoxy)-tetrahydro-pyran 在 4-甲基苯磺酸吡啶 、 lithium diisopropyl amide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2-formyl-5''-hydroxymethyl-alpha-terthiophene
  参考文献：
  名称：

  Novel protein kinase C inhibitors: α-terthiophene derivatives

  摘要：

  A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 mu M). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00468-5
• 作为产物：
  描述：

  2,2':5',2'-四噻吩-5-甲醛 在 sodium tetrahydroborate 、 4-甲基苯磺酸吡啶 作用下， 以 四氢呋喃 为溶剂， 生成 2-([2,2';5',2'']Terthiophen-5-ylmethoxy)-tetrahydro-pyran
  参考文献：
  名称：

  Novel protein kinase C inhibitors: α-terthiophene derivatives

  摘要：

  A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 mu M). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00468-5