Cytotoxin-targeting molecule conjugates comprising cytotoxin and an antibody, growth factor, or polysaccharide together with a pH-sensitive or redox potential-sensitive linker. Novel ansamitocins and recombinant genes and organisms that produce them. The use of the described conjugates in the treatment of cancer and other hyperproliferation diseases.
细胞毒素-靶向分子共轭物,包括细胞毒素和
抗体、生长因子或
多糖,以及 pH 敏感或氧化还原电位敏感的连接体。新型ansamitocins和
重组基因以及产生它们的
生物体。所述共轭物在治疗癌症和其他过度增殖疾病中的应用。