4-[1,4-dioxa-7-azaspiro [4.4] nonan-7-yl] aniline | 877213-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-[1,4-dioxa-7-azaspiro [4.4] nonan-7-yl] aniline
• 英文别名: 4-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)phenylamine；4-(1,4-Dioxa-7-azaspiro[4,4]non-7-yl)phenylamine；4-(1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)aniline
• CAS: 877213-05-3
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: HWHYTOJFRBCMNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[1,4-dioxa-7-azaspiro [4.4] nonan-7-yl] aniline 、 4-丁氧基-2-(2-氯乙基)苯甲酰氯 在 C26H34N2O4 作用下， 生成 6-butoxy-2-[4-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments

  摘要：

  本发明涉及含氮杂环取代的芳基二氢异喹啉酮及其衍生物，其生理耐受盐和生理功能衍生物，其制备方法，至少包括本发明中的一种含氮杂环取代的芳基二氢异喹啉酮或其衍生物的药物，以及将本发明中的含氮杂环取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂。

  公开号：

  US08822495B2
• 作为产物：
  描述：

  对氟硝基苯 在 palladium 10% on activated carbon 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 4-[1,4-dioxa-7-azaspiro [4.4] nonan-7-yl] aniline
  参考文献：
  名称：

  [EN] NOVEL PHENYLAMINOPYRIMIDINE COMPOUND HAVING INHIBITORY ACTIVITY AGAINST LRRK2 AND USE THEREOF
  [FR] NOUVEAU COMPOSÉ DE PHÉNYLAMINOPYRIMIDINE AYANT UNE ACTIVITÉ INHIBITRICE CONTRE LRRK2 ET SON UTILISATION
  [KO] LRRK2에 대해 저해 활성을 갖는 신규한 페닐아미노피리미딘 화합물 및 이의 용도

  摘要：

  本发明提供了一种化学式为1的嘧啶化合物，以及包含该化合物的用于预防或治疗由LRRK2介导或与之相关的疾病（例如帕金森病）的药物组合物，以及使用该组合物治疗和预防疾病或疾病的方法。根据本发明，嘧啶化合物具有优异的LRRK2抑制活性，可有效用于预防或治疗与LRRK2相关的疾病（例如帕金森病）。

  公开号：

  WO2022203466A1

文献信息

• Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040220191A1

  公开（公告）日：2004-11-04

  The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I 1 in which the radicals have the stated meanings, the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.

  这项发明涉及取代N-芳基杂环化合物及其生理耐受盐和生理功能衍生物。式I的化合物 1 其中基团具有所述含义，其N-氧化物及其生理耐受盐以及其制备方法被描述。这些化合物例如适用作为厌食剂。
• NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090264403A1

  公开（公告）日：2009-10-22

  The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryidihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及含氮杂环取代的芳基二氢异喹啉酮及其衍生物、其生理上可耐受的盐和生理功能衍生物、其制备方法、包含本发明中至少一种含氮杂环取代的芳基二氢异喹啉酮或其衍生物的药物以及将本发明中的含氮杂环取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂。
• ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
  申请人：SCHWINK Lothar

  公开号：US20070299077A1

  公开（公告）日：2007-12-27

  The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.

  本发明涉及公式I的芳基取代的多环胺，特别是双环胺，以及其生理耐受的盐和生理功能衍生物；其中符号和基团在说明中解释，以及含有它们的制药组合物和使用它们的治疗方法。
• Substituted N-aryl Heterocycles, Process For Their Preparation and Their Use As Medicaments
  申请人：Schwink Lothar

  公开号：US20070207991A1

  公开（公告）日：2007-09-06

  The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.

  该发明涉及取代的N-芳基杂环化合物及其生理耐受盐和生理功能衍生物。描述了公式I中化合物，其中基团具有所述的含义，以及其N-氧化物和生理耐受盐和其制备方法。这些化合物例如适用于作为抑制食欲的药物。
• Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：US07838547B2

  公开（公告）日：2010-11-23

  The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.

  本发明涉及化学式I中的芳基取代的多环胺，尤其是双环胺，以及其生理上可耐受的盐和生理上功能衍生物。其中符号和基团在说明中解释，以及包含它们的制药组合物和使用它们的治疗方法。