1-(4-甲基苯基)-3-丙基脲 | 13143-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-甲基苯基)-3-丙基脲
• 英文名称: N-4-methylphenyl-N'-propylurea
• 英文别名: 1-(4-methylphenyl)-3-propylurea；N-p-Tolyl-N'-n-propylharnstoff；N-propyl-N'-p-tolyl-urea；N-Propyl-N'-p-tolyl-harnstoff
• CAS: 13143-42-5
• 化学式: C₁₁H₁₆N₂O
• mdl: MFCD00089030
• 分子量: 192.261
• InChiKey: DLYNPHRAQQRBRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-n-propyl-N'-4-tolylcarbodiimide 反应 72.0h， 生成 1-(4-甲基苯基)-3-丙基脲
  参考文献：
  名称：

  Froeyen, Paul, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 81, # 1-4, p. 37 - 48

  摘要：

  DOI：

文献信息

• A Fe₃ O₄ @SiO₂ /Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One-Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas
  作者：Iman Dindarloo Inaloo、Sahar Majnooni

  DOI：10.1002/ejoc.201901140

  日期：2019.10.9

  A palladium‐catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines, and alcohols) in a one‐pot approach. This efficient and phosgene‐free process provided an inexpensive and attractive route to synthesize the products in good to excellent yields.

  通过一锅法使用容易获得且经济的起始原料（芳基卤化物，一氧化碳，叠氮化钠，胺和醇），已经开发了直接催化氨基甲酸酯和脲合成钯催化的多米诺骨牌方法。这种高效且无光气的工艺提供了一种廉价且诱人的途径，可以以良好的收率获得优良的合成产物。
• Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents
  申请人：Sattigeri Vishwajanani Jitendra

  公开号：US20090048186A1

  公开（公告）日：2009-02-19

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

  本发明涉及单糖衍生物作为抗炎剂。本发明的化合物可用于抑制和预防炎症及相关病理，包括炎症和自身免疫疾病，如支气管哮喘、类风湿性关节炎、I型糖尿病、多发性硬化症、异体移植排斥、银屑病、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒和过敏性鼻炎。还提供了含有本发明披露的化合物的药物组合物，以及使用这些化合物治疗支气管哮喘、慢性阻塞性肺病、类风湿性关节炎、多发性硬化症、I型糖尿病、银屑病、异体移植排斥、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒、过敏性鼻炎以及其他炎症性和/或自身免疫障碍的方法。
• Methods for treating Hepatitis C
  申请人：Karp Mitchell Gary

  公开号：US20080096928A9

  公开（公告）日：2008-04-24

  In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

  根据本发明，已经确定了抑制病毒复制的化合物，优选为丙型肝炎病毒（HCV）复制，同时提供了其使用方法。在本发明的一方面，提供了用于治疗或预防病毒感染的化合物。在本发明的另一方面，提供了用于治疗或预防HCV感染的化合物。
• METHODS FOR TREATING HEPATITIS C
  申请人：KARP Gary M.

  公开号：US20110268698A1

  公开（公告）日：2011-11-03

  The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.

  本发明提供了化合物、药物组合物以及使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
• Boehmer, Recueil des Travaux Chimiques des Pays-Bas, 1936, vol. 55, p. 379,383
  作者：Boehmer

  DOI：——

  日期：——