DH98298-170B2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DH98298-170B2
• 英文别名: 4-Arylmaleimide deriv. 6cc；2-chloro-5-[[4-(4-chlorophenyl)-2,5-dioxopyrrol-3-yl]amino]benzoic acid
• 化学式: C₁₇H₁₀Cl₂N₂O₄
• 分子量: 377.183
• InChiKey: ACBZAFIQJQQSBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基-2-氯苯甲酸 、 3-chloro-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione 以 甲醇 为溶剂， 反应 72.0h， 生成 DH98298-170B2
  参考文献：
  名称：

  3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

  摘要：

  Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00721-6

文献信息

• 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
  作者：David G. Smith、Marianne Buffet、Ashley E. Fenwick、David Haigh、Robert J. Ife、Martin Saunders、Brian P. Slingsby、Rachel Stacey、Robert W. Ward

  DOI：10.1016/s0960-894x(00)00721-6

  日期：2001.3

  Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved.