2-[3-[[3-[(6-Methylpyridin-2-yl)carbamoyl]phenyl]iminomethyl]phenyl]acetic acid | 1098180-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-[[3-[(6-Methylpyridin-2-yl)carbamoyl]phenyl]iminomethyl]phenyl]acetic acid
• 英文别名: 2-[3-[[3-[(6-methylpyridin-2-yl)carbamoyl]phenyl]iminomethyl]phenyl]acetic acid
• CAS: 1098180-67-6
• 化学式: C₂₂H₁₉N₃O₃
• 分子量: 373.411
• InChiKey: QLBWQIJYEKQYMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(6-methylpyridin-2-yl)-3-[(triphenyl-lambda5-phosphanylidene)amino]benzamide 、 3-醛基苯乙酸 在 对溴苯乙酸 作用下， 以 氘代氯仿 为溶剂， 生成 2-[3-[[3-[(6-Methylpyridin-2-yl)carbamoyl]phenyl]iminomethyl]phenyl]acetic acid
  参考文献：
  名称：

  Making Imines Without Making Water−Exploiting a Recognition-Mediated Aza-Wittig Reaction

  摘要：

  A recognition-mediated aza-Wittig reaction permits the efficient formation of an imine in dry CDCl3 from an iminophosphorane and an aldehyde. The kinetic and thermodynamic parameters for this reaction are compared with those obtained from a condensation reaction between an aldehyde and an amine that forms the same product.

  DOI：

  10.1021/ol8024499

文献信息

• Making Imines Without Making Water−Exploiting a Recognition-Mediated Aza-Wittig Reaction
  作者：Vicente del Amo、Douglas Philp

  DOI：10.1021/ol8024499

  日期：2009.1.15

  A recognition-mediated aza-Wittig reaction permits the efficient formation of an imine in dry CDCl3 from an iminophosphorane and an aldehyde. The kinetic and thermodynamic parameters for this reaction are compared with those obtained from a condensation reaction between an aldehyde and an amine that forms the same product.