tetrahydronaphthyl thiourea | 91215-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: tetrahydronaphthyl thiourea
• 英文别名: 1,2,3,4-Tetrahydronaphthalen-1-ylthiourea
• CAS: 91215-19-9
• 化学式: C₁₁H₁₄N₂S
• 分子量: 206.312
• InChiKey: RKUOACMNTVFMAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四酮-1-肟 在 氢氧化钾 、 sodium 作用下， 以 丙醇 、 乙醇 、 水 、 丙酮 为溶剂， 反应 3.5h， 生成 tetrahydronaphthyl thiourea
  参考文献：
  名称：

  Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants☆

  摘要：

  A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.05.039

文献信息

• Kinase Inhibitors
  申请人：Van Rompaey Philippe

  公开号：US20090233960A1

  公开（公告）日：2009-09-17

  The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R 1 , R 2 , R 3 , R 31 , n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

  本发明涉及新的AGC激酶抑制剂，特别是公式I、II或III的化合物，或其立体异构体、互变异构体、外消旋体、代谢产物、前药或前制品、盐、水合物或溶剂化物，其中X、R1、R2、R3、R31、n和m在权利要求书中定义。特别地，本发明更具体地涉及ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病中使用这些抑制剂的用途。
• INDANYL-AND TETRAHYDRONAPHTYL-AMINO-THIOUREA COMPOUNDS FOR COMBATING ANIMAL PESTS
  申请人：BASF SE

  公开号：EP1957447A1

  公开（公告）日：2008-08-20
• Indanyl- and Tetrahydronaphtyl-amino-thiourea Compounds for Combating Animal Pests
  申请人：Kordes Markus

  公开号：US20090075819A1

  公开（公告）日：2009-03-19

  The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R 1 to R 4 are as in the description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection.
• US7674827B2
  申请人：——

  公开号：US7674827B2

  公开（公告）日：2010-03-09
• [EN] INDANYL-AND TETRAHYDRONAPHTYL-AMINO-THIOUREA COMPOUNDS FOR COMBATING ANIMAL PESTS<br/>[FR] COMPOSES INDANYL ET TETRAHYDRONAPHTYL-AMINO-THIOUREE UTILISES POUR LUTTER CONTRE LES PARASITES DES ANIMAUX
  申请人：BASF AG

  公开号：WO2007060120A1

  公开（公告）日：2007-05-31

  [EN] Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds for combating animal pests The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R¹ to R⁴ are as in the description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection.
  [FR] La présente invention porte sur des composés indanyl et tétrahydronaphtyl-amino-thiourée qui sont utilisés pour lutter contre les parasites des animaux. Ces composés indanyl- et tétrahydronaphtyl-amino-thiourée sont représentés par la formule I dans laquelle les variables R¹ à R⁴ sont telles que définies dans le descriptif. Cette invention concerne également des procédés de lutte contre les insectes, les arachnides ou les nématodes ou d'élimination de ces derniers, des procédés de protection des plantes en état de croissance contre les attaques ou l'infestation par les insectes, les arachnides ou les nématodes, des procédés de protection des graines contre les insectes terrestres et de protection des racines de semis et des pousses contre les insectes terrestres et les insectes des feuilles ainsi que des procédés de traitement, de lutte, de prévention et de protection contre l'infestation ou l'infection des animaux.