6-(phenylamino)-7-chloroquinazoline-5,8-dione | 740854-81-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(phenylamino)-7-chloroquinazoline-5,8-dione
• 英文别名: 6-Anilino-7-chloroquinazoline-5,8-dione
• CAS: 740854-81-3
• 化学式: C₁₄H₈ClN₃O₂
• 分子量: 285.689
• InChiKey: MAISSZOJEIDTHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,6-二甲氧基-2-硝基苯甲醛 在 盐酸 、 cerium(III) chloride 、 硝酸 、 溶剂黄146 、 锌 作用下， 以 乙醇 为溶剂， 反应 7.0h， 生成 6-(phenylamino)-7-chloroquinazoline-5,8-dione
  参考文献：
  名称：

  6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

  摘要：

  A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.094

文献信息

• Synthesis and Cytotoxic Activity of 6-(Substituted-Phenyl)Amino-5,8-Quinazolinediones
  作者：Chung-Kyu Ryu、You-Jin Yi、Ik Hwa Choi、Mi Jin Chae、Ja-Young Han、Ok-Jai Jung、Chong-Ock Lee

  DOI：10.1007/s00044-004-0032-8

  日期：2004.6

  6-Arylamino-5,8-quinazolinediones were synthesized and evaluated for in vitro cytotoxic activity against human solid tumor cell lines A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Most of the 6-arylamino-5,8-quinazolinediones exhibited potent activity against the cell lines HCT-15 and SK-MEL-2.
• 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents
  作者：Hyen Joo Park、Young-Shin Kim、Jin Sung Kim、Eun-Jin Lee、You-Jin Yi、Hye Jin Hwang、Myung-Eun Suh、Chung-Kyu Ryu、Sang Kook Lee

  DOI：10.1016/j.bmcl.2004.04.094

  日期：2004.7

  A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed. (C) 2004 Elsevier Ltd. All rights reserved.