3,5,11,17-Tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione | 1454712-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3,5,11,17-Tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione
• 英文别名: 3,5,11,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione
• CAS: 1454712-42-5
• 化学式: C₁₃H₆N₄O₂
• 分子量: 250.216
• InChiKey: VCBYHVNIQZEDNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,6-二甲氧基-2-硝基苯甲醛 在 盐酸 、 硝酸 、 potassium carbonate 、 溶剂黄146 、 锌 作用下， 以 乙醇 为溶剂， 反应 8.75h， 生成 3,5,11,17-Tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaene-8,9-dione
  参考文献：
  名称：

  Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

  摘要：

  A new series of substituted tri-/tetraazabenzo[3,2-alpha] fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.08.021

文献信息

• Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives
  作者：Theerachart Leepasert、Manochehr Shahabi、Karem Shanab、Eva Schirmer、Wolfgang Holzer、Helmut Spreitzer、Babette Aicher、Gilbert Müller、Eckhard Günther

  DOI：10.1016/j.bmcl.2013.08.021

  日期：2013.10

  A new series of substituted tri-/tetraazabenzo[3,2-alpha] fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. (C) 2013 Elsevier Ltd. All rights reserved.