2-nitro-N-[(1R,2R)-2-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonylamino]cyclohexyl]-4-(trifluoromethyl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitro-N-[(1R,2R)-2-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonylamino]cyclohexyl]-4-(trifluoromethyl)benzenesulfonamide
• 化学式: C₂₀H₁₈F₆N₄O₈S₂
• 分子量: 620.507
• InChiKey: SYLBEXNEKUBWKT-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  201
• 氢给体数：
  2
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  2-硝基-4-(三氟甲基)苯磺酰氯 、 (1R,2R)-1,2-diaminocyclohexane 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-nitro-N-[(1R,2R)-2-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonylamino]cyclohexyl]-4-(trifluoromethyl)benzenesulfonamide
  参考文献：
  名称：

  Catalytic enantioselective cyclopropanation with bis(halomethyl)zinc reagents. II. The effect of promoter structure on selectivity

  摘要：

  The catalytic, enantioselective cyclopropanation of cinnamyl alcohol has been accomplished with bis(iodomethyl)zinc in the presence of chiral bis(sulfonamides) derived from cyclohexanediamine. An extensive survey of diamine and sulfonamide structure has revealed a marked sensitivity to the spatial relationship of the amine groups, but only a modest dependence on the sulfonamide residue.

  DOI：

  10.1016/0040-4039(95)00259-f

文献信息

• Catalytic enantioselective cyclopropanation with bis(halomethyl)zinc reagents. II. The effect of promoter structure on selectivity
  作者：Scott E. Denmark、Beritte L. Christenson、Stephen P. O'Connor

  DOI：10.1016/0040-4039(95)00259-f

  日期：1995.3

  The catalytic, enantioselective cyclopropanation of cinnamyl alcohol has been accomplished with bis(iodomethyl)zinc in the presence of chiral bis(sulfonamides) derived from cyclohexanediamine. An extensive survey of diamine and sulfonamide structure has revealed a marked sensitivity to the spatial relationship of the amine groups, but only a modest dependence on the sulfonamide residue.