2-benzyl-3-methyl-2-aza-spiro[4.4]nonane | 1015419-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyl-3-methyl-2-aza-spiro[4.4]nonane
• 英文别名: 2-Benzyl-3-methyl-2-azaspiro[4.4]nonane
• CAS: 1015419-99-4
• 化学式: C₁₆H₂₃N
• 分子量: 229.365
• InChiKey: RXOLLXSIDCMIND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1-烯丙基环戊基甲基)苄胺 在 bis(2-(1,3-bis(N-butylimidazol-2-ylidene)phenylene)) bis(μ2-iodo) dirhodium(III) 作用下， 以 氘代苯 为溶剂， 反应 16.0h， 以79%的产率得到2-benzyl-3-methyl-2-aza-spiro[4.4]nonane
  参考文献：
  名称：

  Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir

  摘要：

  The scope of CCC-NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.

  DOI：

  10.1021/ol8000766

文献信息

• Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir
  作者：Eike B. Bauer、G. T. Senthil Andavan、T. Keith Hollis、Ramel J. Rubio、Joon Cho、Glenn R. Kuchenbeiser、Theodore R. Helgert、Christopher S. Letko、Fook S. Tham

  DOI：10.1021/ol8000766

  日期：2008.3.1

  The scope of CCC-NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.