N-(2-氨基-1-苯基乙基)-N,N-二乙胺 | 31788-97-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-氨基-1-苯基乙基)-N,N-二乙胺
• 中文别名: N1,N1-二乙基-1-苯基乙烷-1,2-二胺；(2-氨基-1-苯基-乙基)-二乙基-胺
• 英文名称: N¹,N¹-diethyl-1-phenyl-1,2-ethanediamine
• 英文别名: 2-Phenyl-2-t-diethylamino-ethylamin；N¹,N¹-diethyl-1-phenyl-ethanediyldiamine；N¹,N¹-Diaethyl-1-phenyl-aethandiyldiamin；N1,N1-diethyl-1-phenylethane-1,2-diamine；N-(2-amino-1-phenylethyl)-N,N-diethylamine；N,N-diethyl-1-phenylethane-1,2-diamine
• CAS: 31788-97-3
• 化学式: C₁₂H₂₀N₂
• mdl: MFCD06655136
• 分子量: 192.304
• InChiKey: ZXCVEIVPQIPKIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  N-(2-氨基-1-苯基乙基)-N,N-二乙胺 、 4-<(methylsulfonyl)amino>benzoyl chloride 以 四氢呋喃 为溶剂， 反应 17.0h， 以38%的产率得到N-<2-(diethylamino)-2-phenylethyl>-4-<(methylsulfonyl)amino>benzamide
  参考文献：
  名称：

  Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents

  摘要：

  Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule. Electrophysiological activity was determined by standard microelectrode techniques in canine cardiac Purkinje fibers. Initial assessment of class I efficacy was carried out in a ouabain-induced arrhythmia model in guinea pigs. All of the compounds prolonged action potential duration in Purkinje fibers (class III activity), and three were active against ouabain-induced arrhythmias (class I activity). Selected compounds were evaluated further in dogs for efficacy against arrhythmias occurring 24 h following coronary ligation (automatic arrhythmias) and induced by using programmed electrical stimulation techniques (reentrant arrhythmias). The most effective compounds from the series are 3g and -j, which were effective in both canine models. Molecular modeling and structure-activity relationships are discussed.

  DOI：

  10.1021/jm00164a025
• 作为产物：
  描述：

  (二乙基氨基)苯基-乙腈 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 N-(2-氨基-1-苯基乙基)-N,N-二乙胺
  参考文献：
  名称：

  Welvart, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954, vol. 238, p. 2536

  摘要：

  DOI：

文献信息

• 2-(HETEROARYL) ALKYL INDAZOLE 6-PHENYL AND THIENYL METHYL AMIDE AS THROMBIN INHIBITORS
  申请人：Siegel Stephan

  公开号：US20100105663A1

  公开（公告）日：2010-04-29

  The invention relates to substituted indazoles and methods for production thereof and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases, preferably of thromboembolic diseases.

  本发明涉及取代的吲唑并且其生产方法及其用途，用于生产治疗和/或预防疾病的药物，特别是心血管疾病，优选为血栓栓塞性疾病的药物。
• [EN] PROCESS FOR PREPARING A MODIFIED NATURAL RUBBER BY MEANS OF A MODIFIER<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN CAOUTCHOUC NATUREL MODIFIÉ AU MOYEN D'UN AGENT DE MODIFICATION
  申请人：MICHELIN & CIE

  公开号：WO2016087603A1

  公开（公告）日：2016-06-09

  L 'invention concerne un procédé de préparation d 'un caoutchouc naturel modifié comprenant les étapes suivantes : a) une étape d 'oxydation du caoutchouc naturel conduisant à la génération d'un caoutchouc naturel oxydé, puis b) une étape de réaction du caoutchouc naturel oxydé avec un agent de modification de formule (I) suivante : n étant un nombre entier supérieur ou égal à 1, X étant un atome d' oxygène ou un groupement choisi parmi les alkylènes, les arylènes, les aralkylènes, les alkylenoxy, les arylenoxy et les aralkylenoxy, R étant un groupement interactif vis-à-vis d'une charge renforçante.
• Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents
  作者：Gary B. Phillips、Thomas K. Morgan、Klaus Nickisch、Joan M. Lind、Robert P. Gomez、Ronald A. Wohl、Thomas M. Argentieri、Mark E. Sullivan

  DOI：10.1021/jm00164a025

  日期：1990.2

  Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule. Electrophysiological activity was determined by standard microelectrode techniques in canine cardiac Purkinje fibers. Initial assessment of class I efficacy was carried out in a ouabain-induced arrhythmia model in guinea pigs. All of the compounds prolonged action potential duration in Purkinje fibers (class III activity), and three were active against ouabain-induced arrhythmias (class I activity). Selected compounds were evaluated further in dogs for efficacy against arrhythmias occurring 24 h following coronary ligation (automatic arrhythmias) and induced by using programmed electrical stimulation techniques (reentrant arrhythmias). The most effective compounds from the series are 3g and -j, which were effective in both canine models. Molecular modeling and structure-activity relationships are discussed.
• Welvart, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954, vol. 238, p. 2536
  作者：Welvart

  DOI：——

  日期：——