麦草畏二甲胺盐 | 2300-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 麦草畏二甲胺盐
• 中文别名: 3,6-二氯-2-甲氧基苯甲酸二甲胺盐
• 英文名称: dicamba dimethylammonium salt
• 英文别名: dicamba DMA；3,6-dichloro-2-methoxybenzoate;dimethylazanium
• CAS: 2300-66-5
• 化学式: C₂H₇N*C₈H₆Cl₂O₃
• 分子量: 266.124
• InChiKey: JDRFUUBRGGDEIZ-UHFFFAOYSA-N

物化性质

• 物理描述：
  Dimethylamine dicamba is a colorless to white crystalline powder. Mildly corrosive. Used as an herbicide.

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

代谢

草甘膦大部分以未代谢的形式排出，但也可能与葡萄糖醛酸或甘氨酸结合。

Dicamba is excreted mostly in unmetabolized form but may also be conjugated with glucoronic acid or glycine. /Dicamba/

来源:Hazardous Substances Data Bank (HSDB)

代谢

荷斯坦奶牛通过导管喂食了5 ppm的Banvel-D（2-甲氧基-3,6-二氯苯甲酸）持续4天，每天基于22.7公斤的饲料配给。...在牛奶或粪便中没有检测到残留物；在喂食试验的前4天，只在粪便中发现了Banvel-D的微量（无法量化）。尿液占完整除草剂排泄的73%。从第2天到第7天，尿液中浓度分别为3.4、4.6、4.3、4.2、4.1和0.1 ppm。

Holstein dairy cow was fed by catheter 5 ppm of Banvel-D (2-methoxy-3,6-dichlorobenzoic acid) for 4 days based on 22.7 kg daily feed ration. ...No residues were detected in either the milk or the feces; during the first 4 days of the feeding trial, only traces (not quantitatively measurable) were found of Banvel-D in the feces. The urine accounted for 73% of the excretion of the intact herbicide. From day 2 through day 7, the urinary concentrations were 3.4, 4.6, 4.3, 4.2, 4.1 and 0.1 ppm, respectively.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 其他中枢神经系统神经毒素

Neurotoxin - Other CNS neurotoxin

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

LC50 (大鼠) >5,300 毫克/立方米;

LC50 (rat) >5,300 mg/m3;

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

皮肤污染应立即用肥皂和水清洗处理。眼睛污染应立即用大量清水长时间冲洗眼睛。如果皮肤或眼睛刺激持续存在，应立即获取医疗注意。/其他除草剂/

Skin contamination should be treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be obtained without delay. /Other Herbicides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

这些除草剂被摄入后，很可能会因为其刺激性质而导致呕吐和腹泻。活性炭可能有效限制刺激作用，并减少大部分或所有这些除草剂的吸收。含铝的氢氧化物抗酸剂可能有助于中和大多数酸性物质的刺激作用。如果存在肠道鸣音，且自发腹泻尚未开始，应给予山梨醇以诱导泻药。脱水和电解质紊乱可能严重到需要静脉输液。这些除草剂中毒没有特定的解毒剂。/其他除草剂/

Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to the irritant properties. ... Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of mose acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require intravenous fluids. There are no specific antidotes for poisoning by these herbicides. /Other Herbicides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

如果出现严重的脱水和电解质流失，由于呕吐和腹泻，监测血液电解质和液体平衡，并给予葡萄糖、生理盐水、林格氏液或乳酸林格氏液的静脉输液，以恢复细胞外液量和电解质。一旦能够保留液体，随后给予口服营养。液体有助于支持有毒物质的排泄。对于这些除草剂过度暴露的管理，支持性措施通常已足够。/其他除草剂/

If serious dehydration and electrolyte depletion have occurred as a result of vomiting and diarrhea, monitor blood electrolytes and and fluid balance and administer intravenous infusions of glucose, normal saline ringer's solution, or ringer's lactate to restore extracellular fluid volume and electrolytes. Follow this with oral nutrients as soon as fluids can be retained. Fluids serve to support excretion of the toxicants. Supportive measures are ordinarily sufficient for successful management of excessive exposures to these herbicides. /Other Herbicides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

草甘膦经口服摄入后容易被吸收，但经皮肤接触后吸收量极小。口服摄入后，草甘膦似乎会迅速且非选择性地分布到大多数器官系统。大多数动物研究表明，原始剂量的90%以上最终通过尿液排出。少量草甘膦通过粪便排出，已被证明是真正的消除（在皮下给药后表明）以及未吸收除草剂的排出（在口服暴露后）。... 消除过程迅速，且没有证据表明在哺乳动物系统中会发生生物累积。 /草甘膦/

Dicamba is readily absorbed following ingestion, but only minimal absorption occurs after dermal exposure. Following ingestion, dicamba appears to be rapidly and nonselectively distributed to most organ systems. Most animal studies indicate greater than 90 % of the original dose ultimately undergoes urinary excretion. Small amounts of dicamba are excreted in the feces and have been shown to represent true elimination (indicated after sc administration ) and excretion of unabsorbed herbicide (following oral exposure). ... Elimination occurs rapidly, and there is no evidence of bioaccumulation in mammalian systems. /Dicamba/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  麦草畏二甲胺盐 、 dicamba-potassium salt 、 3,6-dichloro-2-methoxybenzoate sodium salt 、 Dicamba-trolamine 生成 麦草畏
  参考文献：
  名称：

  Herbicidal compositions with substituted phenylsulfonylureas for controlling weeds in rice

  摘要：

  除草剂组合物包括： A）来自公式I的取代苯基磺酰脲化合物组中至少一种具有除草活性的化合物，以及它们在农业上被接受的、即可接受和兼容的盐。其中， R1是（C1-C8）烷基，（C3-C4）烯基，（C3-C4）炔基或（C1-C4）烷基，该基团由卤素和（C1-C2）烷氧基团组成，可以是单取代的，也可以是多取代的； R2是I或CH2NHSO2CH3; R3是甲基或甲氧基； Z是N或CH； B）来自以下化合物组中至少一种具有除草活性的化合物： Ba）对水稻有选择性，主要对抗草本植物的除草剂； Bb）对水稻有选择性，主要对抗双子叶有害植物和莎草科植物的除草剂； Bc）对水稻有选择性，主要对抗莎草科植物的除草剂； Bd）对水稻有选择性，主要对抗草本植物和双子叶有害植物，以及有害莎草科植物的除草剂。

  公开号：

  US06492301B1
• 作为产物：
  描述：

  麦草畏 、 二甲胺 以 水 为溶剂， 生成 麦草畏二甲胺盐
  参考文献：
  名称：

  AQUEOUS HERBICIDAL CONCENTRATES

  摘要：

  本文提供了高浓度水溶性除草剂盐和水不溶性杀虫剂的水基杀虫剂组合物。这些组合物在其他方面是透明的、均匀的、在各种热环境下储存稳定，并在稀释成水后形成稳定乳液。

  公开号：

  US20150105254A1

文献信息

• HERBICIDAL COMPOSITIONS
  申请人：Bayer Aktiengesellschaft

  公开号：US20220053762A1

  公开（公告）日：2022-02-24

  The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

  本发明提供了包含除草活性化合物（A）和（B）的组合物，其中（A）代表通式（I）的一个或多个化合物或其农药兼容盐[组分（A）]，（B）代表一个或多个除草剂[组分（B）]。该申请进一步涉及一种方法和利用本发明的除草组合物来控制有害植物或调节生长。
• [EN] HERBICIDAL COMPOSITION COMPRISING A MIXTURE OF A FIRST HERBICIDE AND PINOXADEN<br/>[FR] COMPOSITION HERBICIDE COMPRENANT UN MÉLANGE D'HERBICIDE ET DE PINOXADEN
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2011107741A1

  公开（公告）日：2011-09-09

  The invention provides a herbicidal composition comprising a mixture of: (a) a first herbicide being a synthetic auxin herbicide (e.g. dicamba, MCPA or 2,4-D) or an acetolactate synthase (ALS) inhibitor herbicide (e.g. triasulfuron, tribenuron-methyl, iodosulfuron-methyl, mesosulfuron-methyl, sulfosulfuron, flupyrsulfuron-methyl, or pyroxsulam); wherein the first herbicide is present in the form of an aluminium salt; wherein the first herbicide is sufficiently acidic, when in a salt-free form, to allow the formation of an aluminium salt thereof; and wherein the first herbicide, when in a salt-free form or when in a non-aluminium salt form, antagonises the herbicidal activity of pinoxaden; and (b) pinoxaden. A further aspect of the invention also provides a method of reducing the antagonistic effect on the control of monocotyledonous weeds in non-oat cereals which is shown by a herbicidal mixture of either a synthetic auxin herbicide with pinoxaden or an ALS inhibitor herbicide with pinoxaden, which comprises applying a herbicidal composition according to the invention. The presence of the first herbicide in the form of an aluminium salt is thought to mitigate the antagonism of the grass-weed-herbicidal activity of pinoxaden which might otherwise occur.

  本发明提供了一种除草组合物，包括以下混合物：(a)第一除草剂，为合成生长素除草剂（例如，百草枯、MCPA或2,4-D）或乙酰乙酸合成酶（ALS）抑制剂除草剂（例如，三唑磺隆、甲基苯磺隆、碘苯磺隆甲酯、甲基梭菌酯、磺苯嘧啶、氟吡磺隆甲酯或吡磺隆）；其中，第一除草剂以铝盐的形式存在；当第一除草剂处于无盐形式时足够酸性，以允许其形成铝盐；当第一除草剂处于无盐形式或非铝盐形式时，会对哌醇的除草活性产生拮抗作用；以及(b)哌醇。本发明的另一个方面还提供了一种减少合成生长素除草剂与哌醇或ALS抑制剂除草剂与哌醇混合物在非燕麦谷物中对一子叶植物杂草控制的拮抗作用的方法，该方法包括使用本发明的除草组合物。第一除草剂以铝盐的形式存在，被认为可以减轻哌醇对草本杂草的除草活性所产生的拮抗作用。
• Improved pesticide formulations
  申请人：Shell Agrar GmbH & Co. KG

  公开号：EP0235773A1

  公开（公告）日：1987-09-09

  The post-emergent control of a broad spectrum of pests is accomplished by the post-emergent application of a pesticidally effective amount of a formulation comprised of at least one post-emergent, foliar absorbed, substantially water insoluble active ingredient dispersed in at least one substantially water miscible polar/nonpolar solvent which has a vapor pressure of not more than 760 mm of Hg at 20°C capable of dissolving a plant cuticle, including the cuticular wax, and, optionally a surface active agent which substantially prevents the active ingredient from precipitating upon dilution of the formulation with water. The formulation is initially applied to the surface of the foliage and is subsequently incorporated therein by the dissolution of the waxy layer of the foliage by the polar/nonpolar solvent.

  利用后发生的控制广谱害虫的效果，通过施用一种有效量的杀虫剂配方来实现，该配方由至少一种后发性、叶面吸收、明显不溶于水的活性成分，分散在至少一种明显可溶于水的极性/非极性溶剂中组成，该溶剂在20°C时的蒸汽压不超过760毫米汞柱，能够溶解植物表皮，包括表皮蜡质，以及可选的表面活性剂，该表面活性剂在配方被稀释成水时，能够有效防止活性成分沉淀。该配方最初施于叶面表面，并随后通过极性/非极性溶剂溶解叶面的蜡质层而被吸收。
• [EN] PROCESS FOR PREPARATION OF HERBICIDAL SALTS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE SELS HERBICIDES
  申请人：NUFARM AUSTRALIA LTD

  公开号：WO2011143690A1

  公开（公告）日：2011-11-24

  A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.

  一种制备芳基取代羧酸除草剂的固体胺盐的方法，包括将芳基取代羧酸除草剂与胺反应以形成胺盐。该方法在醚溶剂中反应芳基取代羧酸除草剂和胺，形成胺盐，并从醚溶剂反应混合物中收集芳基取代羧酸除草剂的胺盐沉淀物，其中醚是一种双脂肪醚，包括至少一个主要脂肪基。
• [EN] AUXIN HERBICIDE COMPOSITION<br/>[FR] COMPOSITION HERBICIDE À BASE D'AUXINE
  申请人：NUFARM AUSTRALIA LTD

  公开号：WO2010071936A1

  公开（公告）日：2010-07-01

  An aqueous liquid herbicide composition comprising a solution of at least one of 2,4-D and dicamba in the form of the monomethylamine salt and at least one of 2,4-D and dicamba in the form of the dimethylamine salt wherein the molar ratio of monomethylamine to dimethylamine is in the range of from 1:20 to 4:6.

  一种水性液体除草剂组合物，包括单甲基胺盐形式的2,4-D和滴喜嘧啶中的至少一种，以及二甲基胺盐形式的2,4-D和滴喜嘧啶中的至少一种，其中单甲基胺和二甲基胺的摩尔比在1:20到4:6的范围内。