thermine tetrahydrochloride | 16632-23-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: thermine tetrahydrochloride
• 英文别名: N'-[3-(3-aminopropylamino)propyl]propane-1,3-diamine;hydrochloride
• CAS: 16632-23-8
• 化学式: C₉H₂₄N₄*4ClH
• 分子量: 334.16
• InChiKey: LDQMAMXXJAFFBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.32
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.1
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氯化铑(三水) 、 thermine tetrahydrochloride 在 sodium hydroxide 、 硝酸 作用下， 生成 trans-{Rh(3,3,3-tet)Cl2}NO3*0.5H2O
  参考文献：
  名称：

  Halliday, R. W.; Court, R. H., Canadian Journal of Chemistry, 1974, vol. 52, p. 3469 - 3473

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-双(3-氨丙基)-1,3-丙二胺 在 盐酸 作用下， 生成 thermine tetrahydrochloride
  参考文献：
  名称：

  CHEMOENZYMATIC SYNTHESES OF POLYAMINES AND TETRAAZAMACROCYCLES

  摘要：

  Syntheses of different open chain polyamines starting from enzymatically prepared bis(amidoesters) are described. Some of these polyamines are also used as precursors in the syntheses of tetraazamacrocycles. This methodology cart also be applied to the synthesis of chiral compounds.

  DOI：

  10.1081/scc-120003392

文献信息

• An Efficient Synthesis of N,N'-Substituted Symmetrical Diamines
  作者：Michel Vaultier、Bertrand Carboni、Pilar Martinez-Fresneda

  DOI：10.1080/00397919208019266

  日期：1992.3

  Abstract N,N'-substituted symmetrical diamines are readily prepared in high yields in a one-pot procedure from diazidoalcanes and dichloroboranes. This approach has been extended to the synthesis of thermine, a tetramine isolated from Thermus Thermophilus.

  摘要 N,N'-取代的对称二胺可以通过一锅法从二叠氮烷和二氯硼烷中以高收率轻松制备。这种方法已扩展到thermine的合成，一种从嗜热栖热菌中分离的四胺。
• Aliphatic amino azides as key building blocks for efficient polyamine syntheses
  作者：Bertrand Carboni、Aziza Benalil、Michel Vaultier

  DOI：10.1021/jo00066a028

  日期：1993.7

  New routes to open-chain polyamines have been developed using aliphatic amino azides as common precursors for the construction of the carbon-nitrogen framework. These alpha,omega-diaminoalkane synthetic equivalents were combined with (omega-halogenoalkyl)dichloroboranes to extend the polyamine chain from the azido moiety. An extension from the free amino group can also be achieved via a Michael type addition with acrylonitrile or a reductive amination with a gamma-azido ketone. Further transformations led to a large variety of regioselectively C- or (and) N-substituted polyamines.
• A New polyamine synthesis.
  作者：B. Carboni、M. Vaultier、R. Carrié

  DOI：10.1016/s0040-4039(00)80276-2

  日期：1988.1
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Rh: SVol.B2, 2.3.2.5, page 199 - 199
  作者：

  DOI：——

  日期：——
• CHEMOENZYMATIC SYNTHESES OF POLYAMINES AND TETRAAZAMACROCYCLES
  作者：Mercedes Rubio、Covadonga Astorga、Ignacio Alfonso、Francisca Rebolledo、Vicente Gotor*

  DOI：10.1081/scc-120003392

  日期：2002.1

  Syntheses of different open chain polyamines starting from enzymatically prepared bis(amidoesters) are described. Some of these polyamines are also used as precursors in the syntheses of tetraazamacrocycles. This methodology cart also be applied to the synthesis of chiral compounds.