2-(1-benzothiophen-7-yl)pyridine | 1402599-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-(1-benzothiophen-7-yl)pyridine
• 英文别名: 2-(1-Benzothiophen-7-yl)pyridine
• CAS: 1402599-49-8
• 化学式: C₁₃H₉NS
• 分子量: 211.287
• InChiKey: LAIPIPPNHLAJNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-benzothiophen-7-yl)pyridine 、 N-(phenylmethylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.58h， 生成 N-(phenyl(7-(2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
  参考文献：
  名称：

  [EN] BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES
  [FR] BENZODIOXÉPINE ET COMPOSÉS DE BENZODIOXINE QUI INTERAGISSENT AVEC LA PROTÉINE RÉGULATRICE DE LA GLUCOKINASE POUR LE TRAITEMENT DU DIABÈTE

  摘要：

  本发明涉及与葡萄糖激酶调节蛋白相互作用的式I或II的化合物，或其药学上可接受的盐。此外，本发明涉及使用这些化合物或其药学上可接受的盐治疗2型糖尿病和其他涉及葡萄糖激酶调节蛋白的疾病和/或症状的方法，以及含有这些化合物或其药学上可接受的盐的药物组合物。

  公开号：

  WO2012138776A1
• 作为产物：
  描述：

  2-溴吡啶 、 2-(1-苯并噻吩-7-基)-4,4,5,5-四甲基-1,3,2-二噁硼烷 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 caesium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.5h， 生成 2-(1-benzothiophen-7-yl)pyridine
  参考文献：
  名称：

  [EN] BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES
  [FR] BENZODIOXÉPINE ET COMPOSÉS DE BENZODIOXINE QUI INTERAGISSENT AVEC LA PROTÉINE RÉGULATRICE DE LA GLUCOKINASE POUR LE TRAITEMENT DU DIABÈTE

  摘要：

  本发明涉及与葡萄糖激酶调节蛋白相互作用的式I或II的化合物，或其药学上可接受的盐。此外，本发明涉及使用这些化合物或其药学上可接受的盐治疗2型糖尿病和其他涉及葡萄糖激酶调节蛋白的疾病和/或症状的方法，以及含有这些化合物或其药学上可接受的盐的药物组合物。

  公开号：

  WO2012138776A1

文献信息

• BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES
  申请人：Bartberger Michael David

  公开号：US20140155415A1

  公开（公告）日：2014-06-05

  The present invention relates to compounds of formula I or II, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

  本发明涉及公式I或II的化合物，或其药学上可接受的盐，其与葡萄糖激酶调节蛋白相互作用。此外，本发明涉及使用这些化合物或其药学上可接受的盐治疗2型糖尿病和其他涉及葡萄糖激酶调节蛋白的疾病和/或状况的方法，以及含有这些化合物或其药学上可接受的盐的制药组合物。
• RUBBER COMPOSITION FOR USE IN TIRES
  申请人：Takeda Shinya

  公开号：US20140155520A1

  公开（公告）日：2014-06-05

  A rubber composition comprises from 2 to 50 parts by weight of an aromatic modified terpene resin having a softening point of ≧100° C., and two types of silica, a silica X and a silica Y, at a total quantity of 60 to 130 parts by weight relative to 100 parts by weight of a diene rubber containing from 5 to 50 weight % of a modified S-SBR having a vinyl content of not lower than 60 weight %. A functional group in the modified S-SBR reacts with a silanol group, a proportion of silica relative to the total quantity of a reinforcing filler containing the silica and carbon black is not lower than 85 weight %, a nitrogen specific surface area of the silica X is not lower than 140 m 2 /g, and a nitrogen specific surface area of the silica Y is not lower than 100 m 2 /g but lower than 140 m 2 /g.
• Rubber Composition for Tire, and Pneumatic Tire
  申请人：The Yokohama Rubber Co., Ltd.

  公开号：US20150099844A1

  公开（公告）日：2015-04-09

  A rubber composition for tires comprises: per 100 parts by weight of diene rubber containing from 5 to 50 wt. % of modified BR having a vinyl unit content of 10 to 60 wt. %, from 2 to 50 parts by weight of an aromatic modified terpene resin having a softening point of 100 to 130° C., and a total content of 60 to 130 parts by weight of two types of silica, that is silica X and silica Y; a proportion of the silica relative to a total amount of a reinforcing filler containing carbon black being 85 wt. % or greater; a nitrogen adsorption specific surface area of the silica X is 140 m 2 /g or greater; and a nitrogen adsorption specific surface area of the silica Y is greater than 100 m 2 /g and less than 140 m 2 /g.
• TIRE RUBBER COMPOSITE AND PNEUMATIC TIRE
  申请人：The Yokohama Rubber Co., LTD.

  公开号：US20150148447A1

  公开（公告）日：2015-05-28

  A rubber composition for tires comprises: per 100 parts by weight of diene rubber containing from 5 to 50 wt. % of terminally modified S-SBR, from 2 to 50 parts by weight of an aromatic modified terpene resin having a softening point of 100° C. or higher. A total content of 60 to 130 parts by weight of two types of silica, that is silica X and silica Y. A functional group of the modified S-SBR has reactivity with a silanol group. A proportion of the silica relative to a total amount of a reinforcing filler containing the silica X, the silica Y, and an optionally compounded carbon black is 85 wt. % or greater. A nitrogen adsorption specific surface area of the silica X is 140 m 2 /g or greater; a nitrogen adsorption specific surface area of the silica Y is greater than 100 m 2 /g and less than 140 m 2 /g.
• US9260600B2
  申请人：——

  公开号：US9260600B2

  公开（公告）日：2016-02-16