3-(p-tolylsulfonyl)-6-nitro-1,2,3-benzoxathiazole 2,2-dioxide | 136061-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(p-tolylsulfonyl)-6-nitro-1,2,3-benzoxathiazole 2,2-dioxide
• 英文别名: N-tosyl-p-nitrobenzoxasulfamate；6-Nitro-3-(4-toluenesulfonyl)-1,2,3-benzoxathiazole 2,2-dioxide；6-nitro-3-(p-tolylsulfonyl)-1,2,3-benzoxathiazole 2,2-dioxide；3-(4-Methylphenyl)sulfonyl-6-nitro-1,2lambda6,3-benzoxathiazole 2,2-dioxide；3-(4-methylphenyl)sulfonyl-6-nitro-1,2λ6,3-benzoxathiazole 2,2-dioxide
• CAS: 136061-87-5
• 化学式: C₁₃H₁₀N₂O₇S₂
• 分子量: 370.364
• InChiKey: XUCNUVMBOVNBJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  143
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3-(p-tolylsulfonyl)-6-nitro-1,2,3-benzoxathiazole 2,2-dioxide 在 sodium azide 作用下， 以 水 、 乙腈 为溶剂， 反应 0.25h， 生成 3H-6-Nitro-1,2,3-benzoxathiazole 2,2-dioxide
  参考文献：
  名称：

  Acidity of Cyclic Sulfamates: Study of Substituted 1,2,3-Benzoxathiazole 2,2-Dioxides and Theoretical Investigation of the Effect of Conformation on Acidity

  摘要：

  Sulfamate 1b, 5-nitro-3-(4-toluenesulfonyl)-1,2,3-benzoxathiazole 2,2- dioxide, was treated with various nucleophiles: imidazole, benzylamine, tert-butylamine, sodium azide, potassium fluoride, pyridine, and sodium hydroxide. The first five attacked the exocyclic (tosyl) sulfur atom. No reaction was observed with the pyridine. The hydroxide ion attacked the endocyclic sulfur atom leading to opening of the benzoxathiazole ring. Several N-unsubstituted cyclic sulfamates, X-3H-1,2,3-benzoxathiazole 2,2-dioxides (2a, X = 5-H; 2b, X = 5-NO2; 2c, X = 5-Me; 2d, X = 5-Br; 2e, X = 5-Cl; 2f, X = 6-NO2; 2g, X = 5,6-Cl,Cl) and the naphtho-fused cyclic sulfamate (2h), were prepared by treatment of the respective N-tosyl compounds (1a-h) with sodium azide or potassium fluoride. The pK(a) values for these compounds were determined by potentiometric titration in 60% v/v EtOH/H2O. A Hammett plot using sigma(m) for 2a-e, sigma(p) for 2f, and both sigma(m) and sigma(p) for 2g gave a rho = 2.74. Ab initio calculations were done using sulfamic acid as a simple sulfamate model to test the effect of the geometry changes on pK(a). The calculations showed that the sulfamate with the ringlike geometry should be 3.6 pK(a) units more acidic than the acyclic sulfamate. This overall change was broken down into three factors affecting the pK(a). The N-S bond rotation accounted for a change of 0.22 units, O-S bond rotation for 2.03 units, and ring strain for 1.36 units.

  DOI：

  10.1021/jo00112a022
• 作为产物：
  描述：

  3-(p-tolylsulfonyl)-1,2,3-benzoxathiazole 2,2-dioxide 在 sodium nitrite 作用下， 以 三氟乙酸 为溶剂， 以59%的产率得到3-(p-tolylsulfonyl)-6-nitro-1,2,3-benzoxathiazole 2,2-dioxide
  参考文献：
  名称：

  1,2,3-Benzoxathiazole 2,2-dioxides: synthesis, mechanism of hydrolysis, and reactions with nucleophiles

  摘要：

  The rates of base-induced hydrolysis of some five-membered cyclic sulfamates, X-3-(p-tolylsulfonyl)-1,2,3-benzoxathiazole 2,2-dioxides (1a, X = H; 1b, X = 5-Me; 1c, X = 5-t-Bu; 1d, X = 5-Br; 1e, X = 5-Cl; 1f, X = 5-Ac; 1g, X = 5-NO2; 8a, X = 6-NO2) were measured in aqueous acetonitrile. The hydrolyses occurred with cleavage of the endocyclic N-SO2 bond. A Hammett plot using sigma-m values for 1a-g and sigma-p for 8a had rho = +2.20. Activation enthalpies and entropies were measured for 1a and for 3-methyl-1,2,3-benzoxathiazole 2,2-dioxide (10). Volumes of activation were determined for 1g and for 8a. The mechanistic profile for hydrolysis resembled that for the saponification of the analogous sultones and cyclic sulfates. These first examples of 1,2,3-benzoxathiazole 2,2-dioxides (1a-g, 8a) were prepared by treating N-(2-hydroxyphenyl)-p-toluenesulfonamides with sulfuryl chloride and triethylamine or by oxidizing the monoxide precursors using m-chloroperbenzoic acid. Treatment of 1a with potassium fluoride gave 1,2,3-benzoxathiazole 2,2-dioxide (9), which was methylated to give 10. Sulfamate 1a was treated with various nucleophilic reagents: phenyllithium, methyllithium, potassium fluoride, methylamine, tert-butylamine, and sodium methoxide. The first three attacked the tosyl sulfur atom and cleaved the exocyclic N-SO2 bond. The amines attacked the endocyclic sulfonyl sulfur atom and cleaved the endocyclic N-SO2 bond. Sodium methoxide attacked both sulfonyl groups.

  DOI：

  10.1021/jo00023a012

文献信息

• Sodium<i>p</i>-nitrobenzoxasulfamate monohydrate
  作者：Turan K. Yazicilar、Omer Andac、Yunus Bekdemir、Halil Kutuk、Veysel T. Yilmaz、William T. A. Harrison

  DOI：10.1107/s0108270101017930

  日期：2002.1.15

  The title compound, alternatively named sodium 6-nitro-3H-1,2,3-benzoxathiazole 2,2-dioxide monohydrate, Na+,C6H3N2O5S-.H2O, consists of chains of NaO7 units, with the seven donor-O atoms coming from two water molecules and five p-nitrobenzoxasulfamate anions. The seven-coordinate geometry around the Na+ ion is described as monocapped trigonal prismatic, but with a large distortion from ideal geometry. Each triangular face is defined by one O atom each from a water molecule, a nitro group and a sulfonyl group. An O atom from a sulfonyl group caps one of the square faces of the trigonal prism in an unsymmetrical fashion. The water molecules and one sulfonyl O atom are involved in bridging adjacent units, as is the nitro group of the anion. The sulfamate ions adopt an antiparallel alignment between the NaO7 units and are connected to each other by C-H...O and pi-pi interactions. The three-dimensional crystal structure is stabilized by a network of strong O-H...N hydrogen bonds.
• 1,2,3-Benzoxathiazole 2,2-dioxides: synthesis, mechanism of hydrolysis, and reactions with nucleophiles
  作者：Kenneth K. Andersen、Diana D. Bray、Sumalee Chumpradit、Michael E. Clark、Gregory J. Habgood、Colin D. Hubbard、Kathleen M. Young

  DOI：10.1021/jo00023a012

  日期：1991.11

  The rates of base-induced hydrolysis of some five-membered cyclic sulfamates, X-3-(p-tolylsulfonyl)-1,2,3-benzoxathiazole 2,2-dioxides (1a, X = H; 1b, X = 5-Me; 1c, X = 5-t-Bu; 1d, X = 5-Br; 1e, X = 5-Cl; 1f, X = 5-Ac; 1g, X = 5-NO2; 8a, X = 6-NO2) were measured in aqueous acetonitrile. The hydrolyses occurred with cleavage of the endocyclic N-SO2 bond. A Hammett plot using sigma-m values for 1a-g and sigma-p for 8a had rho = +2.20. Activation enthalpies and entropies were measured for 1a and for 3-methyl-1,2,3-benzoxathiazole 2,2-dioxide (10). Volumes of activation were determined for 1g and for 8a. The mechanistic profile for hydrolysis resembled that for the saponification of the analogous sultones and cyclic sulfates. These first examples of 1,2,3-benzoxathiazole 2,2-dioxides (1a-g, 8a) were prepared by treating N-(2-hydroxyphenyl)-p-toluenesulfonamides with sulfuryl chloride and triethylamine or by oxidizing the monoxide precursors using m-chloroperbenzoic acid. Treatment of 1a with potassium fluoride gave 1,2,3-benzoxathiazole 2,2-dioxide (9), which was methylated to give 10. Sulfamate 1a was treated with various nucleophilic reagents: phenyllithium, methyllithium, potassium fluoride, methylamine, tert-butylamine, and sodium methoxide. The first three attacked the tosyl sulfur atom and cleaved the exocyclic N-SO2 bond. The amines attacked the endocyclic sulfonyl sulfur atom and cleaved the endocyclic N-SO2 bond. Sodium methoxide attacked both sulfonyl groups.
• Acidity of Cyclic Sulfamates: Study of Substituted 1,2,3-Benzoxathiazole 2,2-Dioxides and Theoretical Investigation of the Effect of Conformation on Acidity
  作者：Kenneth K. Andersen、Martin G. Kociolek

  DOI：10.1021/jo00112a022

  日期：1995.4

  Sulfamate 1b, 5-nitro-3-(4-toluenesulfonyl)-1,2,3-benzoxathiazole 2,2- dioxide, was treated with various nucleophiles: imidazole, benzylamine, tert-butylamine, sodium azide, potassium fluoride, pyridine, and sodium hydroxide. The first five attacked the exocyclic (tosyl) sulfur atom. No reaction was observed with the pyridine. The hydroxide ion attacked the endocyclic sulfur atom leading to opening of the benzoxathiazole ring. Several N-unsubstituted cyclic sulfamates, X-3H-1,2,3-benzoxathiazole 2,2-dioxides (2a, X = 5-H; 2b, X = 5-NO2; 2c, X = 5-Me; 2d, X = 5-Br; 2e, X = 5-Cl; 2f, X = 6-NO2; 2g, X = 5,6-Cl,Cl) and the naphtho-fused cyclic sulfamate (2h), were prepared by treatment of the respective N-tosyl compounds (1a-h) with sodium azide or potassium fluoride. The pK(a) values for these compounds were determined by potentiometric titration in 60% v/v EtOH/H2O. A Hammett plot using sigma(m) for 2a-e, sigma(p) for 2f, and both sigma(m) and sigma(p) for 2g gave a rho = 2.74. Ab initio calculations were done using sulfamic acid as a simple sulfamate model to test the effect of the geometry changes on pK(a). The calculations showed that the sulfamate with the ringlike geometry should be 3.6 pK(a) units more acidic than the acyclic sulfamate. This overall change was broken down into three factors affecting the pK(a). The N-S bond rotation accounted for a change of 0.22 units, O-S bond rotation for 2.03 units, and ring strain for 1.36 units.