4-butyryl-1,2-diphenyl-pyrazolidine-3,5-dione | 13167-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-butyryl-1,2-diphenyl-pyrazolidine-3,5-dione
• 英文别名: 4-Butyryl-1,2-diphenyl-pyrazolidin-3,5-dion；4-Butanoyl-1,2-diphenylpyrazolidine-3,5-dione
• CAS: 13167-98-1
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: CYMACLCYSZCRBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-butyryl-1,2-diphenyl-pyrazolidine-3,5-dione 、 formamide 生成 4-(1-amino-butyl)-1,2-diphenyl-pyrazolidine-3,5-dione
  参考文献：
  名称：

  Logemann et al., Chemische Berichte, 1955, vol. 88, p. 1353,1359

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-二苯-3,5吡唑二酮 、 丁酰氯 在 三氯化铝 、 氯仿 作用下， 生成 4-butyryl-1,2-diphenyl-pyrazolidine-3,5-dione
  参考文献：
  名称：

  Logemann et al., Chemische Berichte, 1955, vol. 88, p. 1353,1359

  摘要：

  DOI：

文献信息

• QUICK DISINTEGRATION TABLET AND METHOD OF PRODUCING THE SAME
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1839650A1

  公开（公告）日：2007-10-03

  To provide a production method of a rapidly disintegrating tablet, the method that has versatility and, without a specialized device, can efficiently produce rapidly disintegrating tablets having a desired rapid disintegration property and sufficient strength. And also to provide such rapidly disintegrating tablets produced by the method, the tablets that can be easily swallowed by people such as the elderly, children and patients having a poor swallowing capability and that have sufficient strength, so that they can endure breakage and abrasion in processes such as distribution and storage and dispensing processes by tablet packing machines. The method of such rapidly disintegrating tablet includes: (1) mixing an active ingredient, an acrylic copolymer and at least a pharmaceutically acceptable additive to obtain a mixture thereof (2) tableting the mixture to obtain a compact, and (3) isothermally heating the compact at a temperature of 50°C to 100°C for a given period of time. And also to provide such rapidly disintegrating tablets produced by the production method of a rapidly disintegrating tablet.

  提供一种快速崩解片剂的生产方法，该方法具有多功能性，无需专用设备即可高效生产出具有所需快速崩解特性和足够强度的快速崩解片剂。同时，提供用该方法生产的快速崩解片剂，这些片剂易于被老人、儿童和吞咽能力差的病人等人群吞咽，并具有足够的强度，使其能够在片剂包装机的分发、储存和分装等过程中经受破损和磨损。这种快速崩解片剂的方法包括(1) 将一种活性成分、一种丙烯酸共聚物和至少一种药学上可接受的添加剂混合，以获得其混合物；(2) 将该混合物制成片剂，以获得压制物；以及 (3) 在 50°C 至 100°C 的温度下等温加热该压制物一段时间。并提供通过快速崩解片剂的生产方法生产的这种快速崩解片剂。
• Lauria; Zamboni, Gazzetta Chimica Italiana, 1957, vol. 87, p. 27,32
  作者：Lauria、Zamboni

  DOI：——

  日期：——
• Certain 4-acyl-1, 2-diphenyl-3, 5-dioxopyrazolidines
  申请人：ERBA CARLO SPA

  公开号：US02873278A1

  公开（公告）日：1959-02-10
• Rapidly Disintegrating Tablet and Production Method Thereof
  申请人：Suzuki Toshio

  公开号：US20080063710A1

  公开（公告）日：2008-03-13

  To provide a production method of a rapidly disintegrating tablet, the method that has versatility and, without a specialized device, can efficiently produce rapidly disintegrating tablets having a desired rapid disintegration property and sufficient strength. And also to provide such rapidly disintegrating tablets produced by the method, the tablets that can be easily swallowed by people such as the elderly, children and patients having a poor swallowing capability and that have sufficient strength, so that they can endure breakage and abrasion in processes such as distribution and storage and dispensing processes by tablet packing machines. The method of such rapidly disintegrating tablet includes: (1) mixing an active ingredient, an acrylic copolymer and at least a pharmaceutically acceptable additive to obtain a mixture thereof (2) tableting the mixture to obtain a compact, and (3) isothermally heating the compact at a temperature of 50° C. to 100° C. for a given period of time. And also to provide such rapidly disintegrating tablets produced by the production method of a rapidly disintegrating tablet.