bis(4-(dimethylamino)phenyl)(phenyl)phosphine oxide | 803-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-(dimethylamino)phenyl)(phenyl)phosphine oxide
• 英文别名: bis(4-(N,N'-dimethylamine)phenyl)phenylphosphine oxide；4,4'-(Phenylphosphoryl)bis(N,N-dimethylaniline)；4-[[4-(dimethylamino)phenyl]-phenylphosphoryl]-N,N-dimethylaniline
• CAS: 803-20-3
• 化学式: C₂₂H₂₅N₂OP
• 分子量: 364.427
• InChiKey: HYOQYTRPSJRQNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[benzyl-bromo-[4-(dimethylamino)phenyl]-phenyl-λ5-phosphanyl]-N,N-dimethylaniline 生成 bis(4-(dimethylamino)phenyl)(phenyl)phosphine oxide
  参考文献：
  名称：

  CAIRNS, S. MATTHEW;MCEWEN, WILLIAM E., HETEROATOM CHEM., 1,(1990) N, C. 9-19

  摘要：

  DOI：

文献信息

• Nickel-Catalyzed C–P Cross-Coupling of Arylboronic Acids with P(O)H Compounds
  作者：Gaobo Hu、Weizhu Chen、Tingting Fu、Zhimin Peng、Hongwei Qiao、Yuxing Gao、Yufen Zhao

  DOI：10.1021/ol402672e

  日期：2013.10.18

  A novel and efficient Ni-catalyzed coupling of a wide range of arylboronic acids with H-phosphites, H-phosphinate esters, and H-phosphine oxides has been developed, providing a general and powerful tool for the synthesis of various aryl-phosphorus compounds, especially for valuable triarylphosphine oxides, in good to excellent yield. This protocol is the first Ni-catalyzed C–P bond-forming reaction

  已开发出新颖且有效的Ni催化的各种芳基硼酸与H-亚磷酸酯，H-次膦酸酯和H-膦氧化物的偶联物，为合成各种芳基-磷化合物提供了通用而有力的工具，特别是对于有价值的三芳基膦氧化物，收率好至极好。该方案是芳基硼酸和P（O）H化合物之间第一个Ni催化的C–P键形成反应。
• Copper-Catalyzed P-Arylation via Direct Coupling of Diaryliodonium Salts with Phosphorus Nucleophiles at Room Temperature
  作者：Jian Xu、Pengbo Zhang、Yuzhen Gao、Yiyin Chen、Guo Tang、Yufen Zhao

  DOI：10.1021/jo4012199

  日期：2013.8.16

  A new method for copper-catalyzed P-C bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.
• CAIRNS, S. MATTHEW;MCEWEN, WILLIAM E., HETEROATOM CHEM., 1,(1990) N, C. 9-19
  作者：CAIRNS, S. MATTHEW、MCEWEN, WILLIAM E.

  DOI：——

  日期：——