6-(Benzyloxymethyl)-5-methyl-1,1-dioxo-1,2,6-thiadiazin-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(Benzyloxymethyl)-5-methyl-1,1-dioxo-1,2,6-thiadiazin-3-one
• 英文别名: 5-methyl-1,1-dioxo-6-(phenylmethoxymethyl)-1,2,6-thiadiazin-3-one
• 化学式: C₁₂H₁₄N₂O₄S
• 分子量: 282.32
• InChiKey: ORFWTDNRDQHVOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  acetoxymethyl benzyl ether 、 3,6-dihydro-5-methyl-3-oxo-2H-1,2,6-thiadiazine 1,1-dioxide 在 三氟化硼乙醚 、 六甲基二硅氮烷 作用下， 生成 6-(Benzyloxymethyl)-5-methyl-1,1-dioxo-1,2,6-thiadiazin-3-one 、 2,6-Bis(benzyloxymethyl)-5-methyl-1,1-dioxo-1,2,6-thiadiazin-3-one
  参考文献：
  名称：

  Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides

  摘要：

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.

  DOI：

  10.1080/07328319708001347

文献信息

• Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides
  作者：A. I. Esteban、E. De Clercq、A. Martinez

  DOI：10.1080/07328319708001347

  日期：1997.3

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.