AAD 1154 | 478932-64-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: AAD 1154
• 英文别名: N-[2-cyano-1-(2,5-dichlorophenoxy)propan-2-yl]-4-(trifluoromethoxy)benzamide
• CAS: 478932-64-8
• 化学式: C₁₈H₁₃Cl₂F₃N₂O₃
• 分子量: 433.214
• InChiKey: LCRHPJDLDGODHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-amino-3-(2,5-dichlorophenoxy)-2-methylpropanenitrile 、 4-(三氟甲氧基)苯甲酰氯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 AAD 1154
  参考文献：
  名称：

  氨基乙腈衍生物的发现，这是一类新型的合成驱虫药。

  摘要：

  已经发现了一系列新的氨基乙腈衍生物（AAD），它们对寄生的线虫物种（例如，弯扭线虫和棒状毛线虫）表现出较高的驱虫活性。重要的是，这些化合物还显示出抗线虫菌株的活性，该菌株对目前可用的广谱驱虫药具有抗性。介绍了其发现，合成，构效关系和生物学结果。

  DOI：

  10.1016/j.bmcl.2008.03.071

文献信息

• ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：US20160213640A1

  公开（公告）日：2016-07-28

  The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R 1 is a hydrogen atom, an alkyl group and the like, R 2 , R 3 , and R 4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R 5 and R 6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar 1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO 2 —, or —N(R 7 )— wherein R 7 is a hydrogen atom, a (C 1 -C 6 )alkyl group and the like, or a pharmacologically acceptable salt thereof.

  本发明涉及一种具有高安全性和优越抗癌活性的抗癌剂，以及一种含有氨基乙腈化合物作为活性成分的抗癌剂，所述氨基乙腈化合物由以下式(I)表示：其中R1为氢原子、烷基等，R2、R3和R4相同或不同，每个为氢原子、烷基等，R5和R6相同或不同，每个为氢原子、卤原子等，m为0或1，R为卤原子、氰基、硝基、苯基（可选择地由烷基取代）等，烷基等，Ar1为苯基、萘基、吡啶基、吡唑基等，每个均可选择地由卤原子、氰基、硝基、烷基等取代，W为—O—、—S—、—SO2—或—N(R7)—，其中R7为氢原子、(C1-C6)烷基等，或其药理学上可接受的盐。
• [EN] ANTI CANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT<br/>[FR] AGENT ANTICANCÉREUX COMPRENANT UN COMPOSÉ D'AMINOACÉTONITRILE EN TANT QUE PRINCIPE ACTIF
  申请人：NIHON NOHYAKU CO LTD

  公开号：WO2016137010A1

  公开（公告）日：2016-09-01

  The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is -O-, -S-, -SO2-, or -N(R7)- wherein R7 is a hydrogen atom, a (C1-C6) alkyl group and the like, or a pharmacologically acceptable salt thereof.

  本发明涉及一种具有高安全性和优越抗癌活性的抗癌药物，该抗癌药物含有作为活性成分的氨基乙腈化合物，其化学式表示为（I），其中R1是氢原子、烷基等，R2、R3和R4相同或不同，每个是氢原子、烷基等，R5和R6相同或不同，每个是氢原子、卤原子等，m为0或1，R是卤原子、氰基、硝基、苯基（可选择地由烷基取代）等，Ar1是苯基、萘基、吡啶基、吡唑基等，每个基可选择地由卤原子、氰基、硝基、烷基等取代，W是-O-、-S-、-SO2-或-N(R7)-，其中R7是氢原子、（C1-C6）烷基等，或其药理学上可接受的盐。
• Amidoacetonitrile derivatives
  申请人：Gauvry Noelle

  公开号：US20070072944A1

  公开（公告）日：2007-03-29

  The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.

  本发明涉及一般式（I）中X、Y和W具有权利要求1中所给出的意义及其对映异构体的化合物。这些活性成分具有优良的杀虫性能。它们特别适用于控制温血动物体内和体外的寄生虫。
• Amidoacetonitrile Derivatives
  申请人：Gauvry Noelle

  公开号：US20090176868A1

  公开（公告）日：2009-07-09

  The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.

  本发明涉及一般式（I）的化合物，其中X，Y和W具有权利要求1中给出的意义，且包括其对映体。这些活性成分具有优良的杀虫特性。它们特别适用于控制温血动物体内外的寄生虫。
• KINASE INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Pitney Pharmaceuticals Pty Limited

  公开号：EP3061451A1

  公开（公告）日：2016-08-31

  The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoacetonitrile derivatives (AADs) in the treatment of cancer.

  本发明涉及用于治疗癌症的激酶抑制剂。具体来说，本发明涉及氨基乙腈衍生物（AADs）在治疗癌症中的应用。