4-bromo-2-ethyl-6-methylphenol | 7564-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-bromo-2-ethyl-6-methylphenol
• 英文别名: 4-Brom-2-ethyl-6-methyl-phenol
• CAS: 7564-39-8
• 化学式: C₉H₁₁BrO
• 分子量: 215.09
• InChiKey: AVRCTMZRINPLPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-溴丙氧基)-4-(三氟甲氧基)苯 、 4-bromo-2-ethyl-6-methylphenol 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到4-bromo-2-ethyl-6-methyl-1-[3-(4-trifluoromethoxyphenoxy)propyloxy]benzene
  参考文献：
  名称：

  Dihalopropene compounds, insecticidal/acaricidal agents containing same,

  摘要：

  通用公式\x9bI!的二卤代丙烯化合物具有出色的杀虫/杀螨活性，因此它们对有害昆虫、螨和蜱的控制效果令人满意。

  公开号：

  US05872137A1
• 作为产物：
  描述：

  2-甲基-6-乙基苯胺 在 盐酸 、 溴 、 sodium nitrite 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 2.25h， 生成 4-bromo-2-ethyl-6-methylphenol
  参考文献：
  名称：

  WO2006/100009

  摘要：

  公开号：

文献信息

• [EN] PYRAZOLE DERIVATIVES AS S1P1 AGONISTS<br/>[FR] DÉRIVÉS DU PYRAZOLE EN TANT QU'AGONISTES S1P1
  申请人：ALMIRALL SA

  公开号：WO2011144338A1

  公开（公告）日：2011-11-24

  The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by sphingosine-1-phosphate receptors (S1P1) agonists.

  本发明涉及式(I)的化合物，制备此类化合物的方法以及它们在治疗可通过鞘氨醇-1-磷酸受体（S1P1）激动剂改善的病理状况或疾病中的用途。
• New pyrazole derivatives
  申请人：Almirall, S.A.

  公开号：EP2390252A1

  公开（公告）日：2011-11-30

  The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by sphingosine-1-phosphate receptors (S1P1) agonists.

  本发明涉及式(I)的化合物，其制备过程，以及它们在治疗可通过sphingosine-1-phosphate受体（S1P1）激动剂改善的病理状况或疾病中的用途。
• Dihalopropene compounds, their use as insecticides/acaricides and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06140274A1

  公开（公告）日：2000-10-31

  Dihalopropene compounds of the general formula: ##STR1## wherein R.sup.1 is substituted alkyl; R.sup.2, R.sup.3 and R.sup.4 are each independently halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro or cyano; A is O, S(O).sub.t or NR.sup.14 in which R.sup.14 is H or alkyl and t is 0 to 2; B is substituted alkylene, alkenylene or alkynylene; r is 0 to 2; X's are each independently halogen; Y is O, S or NH; Z is O, S or NR.sup.25 in which R.sup.25 is H, acetyl or alkyl, which are useful as active ingredients of insecticidal/acaricidal agents.

  二卤代丙烯化合物的一般式：##STR1##其中R.sup.1是取代烷基；R.sup.2、R.sup.3和R.sup.4分别独立为卤素、烷基、卤代烷基、烷氧基、卤代烷氧基、硝基或氰基；A为O、S(O).sub.t或NR.sup.14，其中R.sup.14为H或烷基，t为0至2；B为取代烷基、烯基或炔基；r为0至2；X分别为卤素；Y为O、S或NH；Z为O、S或NR.sup.25，其中R.sup.25为H、乙酰基或烷基，这些化合物可作为杀虫/杀螨剂的活性成分。
• Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
  申请人：Mueller Georg Stephan

  公开号：US20070072847A1

  公开（公告）日：2007-03-29

  The present invention relates to the CGRP-antagonists of general formula I wherein R 1 , R 2 , R 3 and R 4 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一般式I的CGRP拮抗剂，其中R1、R2、R3和R4如权利要求1中所定义，其互变异构体、同分异构体、对映异构体、旋光异构体、水合物、其混合物及其盐以及其盐的水合物，特别是其与无机或有机酸或碱形成的生理上可接受的盐，以及一般式I中一个或多个氢原子被氘取代的化合物，含有这些化合物的药物组合物，它们的用途和制备它们的方法。
• Dihalopropene compounds, insecticides containing them as active
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05952386A1

  公开（公告）日：1999-09-14

  The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 alkyl or the like; L is C(.dbd.O)NH or the like; R.sub.2, R.sub.3 and R.sub.4 are independently halogen or the like; R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or the like; m is an integer of 0 to 4; n is an integer of 0 to 2; X is chlorine or the like; Y is oxygen or the like; and Z is oxygen or the like, which have excellent insecticidal activity so that they are satisfactorily effective for the control of noxious insects.

  本发明提供了一般式为：##STR1##的二卤代丙烯化合物，其中R.sub.1为C.sub.1-C.sub.10烷基或类似物；L为C(.dbd.O)NH或类似物；R.sub.2、R.sub.3和R.sub.4独立地为卤素或类似物；R.sub.5、R.sub.6和R.sub.7独立地为氢或类似物；m为0至4的整数；n为0至2的整数；X为氯或类似物；Y为氧或类似物；Z为氧或类似物，具有优异的杀虫活性，因此对有害昆虫的控制非常有效。