4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one | 79836-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one
• 英文别名: 4-(p-fluorophenyl)-1-tetralone；4-(4-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one；4-(4-fluorophenyl)-alpha-tetralone；4-(4-Fluorophenyl)-3,4-dihydro-1(2h)-naphthalenone；4-(4-fluorophenyl)-3,4-dihydro-2H-naphthalen-1-one
• CAS: 79836-47-8；79560-24-0
• 化学式: C₁₆H₁₃FO
• 分子量: 240.277
• InChiKey: SLEXBQDLWLDRGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one 在 sodium tetrahydroborate 、 对甲苯磺酸 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 2.5h， 生成 1-(4-fluorophenyl)-1,2-dihydronaphthalene
  参考文献：
  名称：

  Metal-free synthesis of indanes by iodine(III)-mediated ring contraction of 1, 2-dihydronaphthalenes

  摘要：

  A metal-free protocol was developed to synthesize indanes by ring contraction of 1,2-dihydronaphthalenes promoted by PhI(OH) OTs (HTIB or Koser's reagent). This oxidative rearrangement can be performed in several solvents (MeOH, CH3CN, 2,2,2-trifluoroethanol (TFE), 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), and a 1: 4 mixture of TFE: CH2Cl2) under mild conditions. The ring contraction diastereoselectively gives functionalized trans-1,3-disubstituted indanes, which are difficult to obtain in synthetic organic chemistry.

  DOI：

  10.1590/s0103-50532011000900024
• 作为产物：
  描述：

  4-(4-Fluorophenyl)-4-phenylbutanoic acid 在 氢氟酸 作用下， 以69%的产率得到4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one
  参考文献：
  名称：

  Antidepressant derivatives of

  摘要：

  新型的4-苯基-1,2,3,4-四氢-1-萘胺的顺式异构衍生物可用作抗抑郁剂。这些新型化合物通过阻断血清素（5-羟色胺）的突触前摄取，从而缓解中枢受体位点的血清素异常。首选实施例是顺式异构体cis-(1S)-N-甲基-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺及其药学上可接受的酸盐。

  公开号：

  US04536518A1

文献信息

• [EN] SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRAZOLO[3,4-B]PYRIDINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010078427A1

  公开（公告）日：2010-07-08

  The present invention relates to substituted imidazoly 1-5,6- dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代咪唑基-5,6-二氢苯并[ｎ]异喹啉化合物及合成这些化合物的方法。本发明还涉及含有替代咪唑基-5,6-二氢苯并[ｎ]异喹啉化合物的药物组合物，以及通过向需要的受试者投予这些化合物和药物组合物来治疗细胞增殖性疾病，如癌症的方法。
• SUBSTITUTED IMIDAZOLYL-5,6-DIHYDROBENZO[N]ISOQUINOLINE COMPOUNDS
  申请人：Ali Syed M.

  公开号：US20100239526A1

  公开（公告）日：2010-09-23

  The present invention relates to substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物及其合成方法。本发明还涉及含有取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物的制药组合物，以及通过向需要治疗细胞增殖性疾病（如癌症）的受试者施用这些化合物和制药组合物来治疗的方法。
• SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
  申请人：Ali Syed M.

  公开号：US20100239525A1

  公开（公告）日：2010-09-23

  The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病的受试者来治疗癌症等细胞增殖性疾病的方法。
• 6-Phenyl-1,2,3,4,4a,5,6,10b-octahydrobenz(h) isoquinolines
  申请人：PENNWALT CORPORATION

  公开号：EP0201085A2

  公开（公告）日：1986-11-12

  The application describes new compounds of the formula wherein R1 is hydrogen, C1-C7 alkyl, or C4-C8 cycloalkylmethyl; R2 is a single or multiple substitution of hydrogen, hydroxyl, C1-C7 alkoxy, or C1-C7 alkyl; and R3 is a single or multiple substitution of hydrogen, hydroxyl, halogen, C1-C7 alkoxy, phenoxy, C1-C7 alkyl, or trifluoromethyl; all stereoisomeric forms and mixtures thereof, and pharmaceutically acceptable addition salts thereof.

  该申请描述了如下式子的新化合物 式中 R1 是氢、C1-C7 烷基或 C4-C8 环烷基甲基； R2 是氢、羟基、C1-C7 烷氧基或 C1-C7 烷基的单个或多个取代基；以及 R3 是氢、羟基、卤素、C1-C7 烷氧基、苯氧基、C1-C7 烷基或三氟甲基的单个或多个取代基； 所有立体异构体形式及其混合物，以及其药学上可接受的加成盐。
• Application of (2-cyanoaryl)arylacetonitriles in cyclization and annulation reactions. Preparation of 3-arylindans, 4-aryl-3,4-dihydronaphthalenes, 4-arylisoquinolines, 1-aminonaphthalenes, and heterocyclic analogues
  作者：Michael Bech Sommer、Mikael Begtrup、Klaus Peter Boegesoe

  DOI：10.1021/jo00303a012

  日期：1990.8