2-[(2-氯苯甲酰基)氨基]苯甲酰胺 | 4765-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(2-氯苯甲酰基)氨基]苯甲酰胺
• 英文名称: N-(2-Chlor-benzoyl)-anthranilamid
• 英文别名: N-(o-Chlorbenzoil)anthranilamid；N-o-Cl-Benzoyl-anthranilamid；N-(2-chloro-benzoyl)-anthranilic acid amide；N-(2-Chlor-benzoyl)-anthranilsaeure-amid；2-[(2-Chlorobenzoyl)amino]benzamide
• CAS: 4765-49-5
• 化学式: C₁₄H₁₁ClN₂O₂
• 分子量: 274.707
• InChiKey: VORNVFBTYKBDHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(2-氯苯甲酰基)氨基]苯甲酰胺 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 2-(2-chlorophenyl)quinazolin-4(3H)-one
  参考文献：
  名称：

  嘧啶和咪唑并喹唑啉酮的多米诺合成

  摘要：

  一种简单的合成N-烷基-2-芳基喹唑啉-4-胺，4-（（（2-芳基喹唑啉-4-基）氨基）丁酸甲酯，6-芳基-2-3,3-二氢-4 H-嘧啶基的方法已经描述了[1,2 - c ]喹唑啉-4-酮和5-芳基咪唑[1,2 - c ]喹唑啉-3（2 H）-酮。它涉及N-（2-氰基苯基）-取代的苯甲酰氯与烷基胺，γ-氨基丁酸，β-丙氨酸，l的简单反应丙氨酸和甘氨酸甲酯盐酸盐在乙腈中，经过一系列包括Dimroth重排的瞬时反应后，可提供所需的化合物。该反应包括回流12小时，将试剂简单地添加到原位生成的苯二甲酰氯中，并且简单地后处理，以高收率形成21个纯化合物的实例。活性中间体ñ - （2-氰基苯基）-substitutedbenzimidoyl氯化物通过反应形成的Ñ - （2-氰基苯基）-substitutedbenzamides与在亚硫酰氯一锅策略。为该制备方法描述的替代方法涉及从邻氨基苯甲酸开始的详尽的多步反应。

  DOI：

  10.1002/jhet.3864
• 作为产物：
  描述：

  N-(2-chlorobenzoyl)anthranilic acid 在 乙醇 、 氨 作用下， 生成 2-[(2-氯苯甲酰基)氨基]苯甲酰胺
  参考文献：
  名称：

  THE SO-CALLED ACYLANTHRANILS (3,1,4-BENZOXAZONES). I. PREPARATION; REACTIONS WITH WATER, AMMONIA, AND ANILINE; STRUCTURE¹

  摘要：

  DOI：

  10.1021/jo01158a006

文献信息

• One-pot Synthesis of Quinazolinone and Benzamide Derivatives Using SBA-Pr-SO3H as a Nanoporous Heterogeneous Acid Catalyst
  作者：Monireh Nahad、Ghodsi Ziarani

  DOI：10.13005/ojc/290443

  日期：2013.12.30

  A series of quinazolinone and benzamide derivatives have been efficiently synthesized in good to excellent yields via the reaction of 2-aminobenzamide and aromatic benzoyl chlorides under solvent-free conditions using SBA-Pr-SO3H as a nano solid acid catalyst.

  一系列的喹嗪酮和苯酰胺衍生物通过在无溶剂条件下使用SBA-Pr-SO3H作为纳米固体酸催化剂，采用2-氨基苯酰胺与芳香族苯甲酰氯反应，已高效合成，产率良好至优异。
• Ramana; Sundaram; Eswara Yuvaraj, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 8, p. 905 - 908
  作者：Ramana、Sundaram、Eswara Yuvaraj、Ganesh Babu

  DOI：——

  日期：——
• Old Adults Exhibit Greater Motor Output Variability Than Young Adults Only During Rapid Discrete Isometric Contractions
  作者：E. A. Christou、L. G. Carlton

  DOI：10.1093/gerona/56.12.b524

  日期：2001.12.1

  The purpose of this study was to examine the ability of young and elderly individuals to control submaximum levels of force (5-90%) during continuous and rapid discrete isometric contractions of the quadriceps femoris. Participants were 24 young (25.3 +/- 2.8 years) and 24 elderly individuals (73.3 +/- 5.5 years) that were healthy and active. The strength of elderly participants was approximately 40% lower than young participants. The standard deviation and coefficient of variation (CV) of force were greater during discrete contractions than during continuous isometric contractions. During continuous isometric contractions, young and elderly participants exhibited similar CVs of force. During discrete contractions, however, elderly participants exhibited greater CVs for peak force and impulse and greater standard deviations and CVs for temporal characteristics than young participants. Results suggest that the control of force in active elderly people declines only during rapid discrete contractions and that this decline may be associated with declines in temporal characteristics of the force production.
• Dass et al., Journal Of Scientific and Industrial Research, 1952, vol. 11 B, p. 461
  作者：Dass et al.

  DOI：——

  日期：——