1-氯-4-[2-(4-甲基苯基)乙基]苯 | 89165-07-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-氯-4-[2-(4-甲基苯基)乙基]苯
• 英文名称: 1-(p-tolyl)-2-(p-chlorophenyl)ethane
• 英文别名: 1-(4-methylphenyl)-2-(4-chlorophenyl)ethane；1-chloro-4-(4-methylphenethyl)benzene；1-(p-Chlorphenyl)-2-tolylethan；1-Chloro-4-[2-(4-methylphenyl)ethyl]benzene
• CAS: 89165-07-1
• 化学式: C₁₅H₁₅Cl
• 分子量: 230.737
• InChiKey: VOLJNJDVXAMHMQ-UHFFFAOYSA-N

物化性质

• 沸点：
  308.5±11.0 °C(Predicted)
• 密度：
  1.092±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-氯-4-[2-(4-甲基苯基)乙基]苯 在 lithium aluminium tetrahydride 、 二氧化碳 、 lithium 作用下， 生成 [4-[2-(4-甲基苯基)乙基]苯基]甲醇
  参考文献：
  名称：

  Carbon-hydrogen vs. carbon-carbon bond cleavage of 1,2-diarylethane radical cations in acetonitrile-water

  摘要：

  DOI：

  10.1021/jo00183a023
• 作为产物：
  描述：

  (4-甲基苄基)三苯基溴化膦 在 硼烷 、 溶剂黄146 作用下， 生成 1-氯-4-[2-(4-甲基苯基)乙基]苯
  参考文献：
  名称：

  Carbon-hydrogen vs. carbon-carbon bond cleavage of 1,2-diarylethane radical cations in acetonitrile-water

  摘要：

  DOI：

  10.1021/jo00183a023

文献信息

• “Bulky-Yet-Flexible” α-Diimine Palladium-Catalyzed Reductive Heck Cross-Coupling: Highly Anti-Markovnikov-Selective Hydroarylation of Alkene in Air
  作者：Xu-Wen Yang、Dong-Hui Li、A-Xiang Song、Feng-Shou Liu

  DOI：10.1021/acs.joc.0c01509

  日期：2020.9.18

  regioselective and efficient reductive Heck reaction, a series of moisture- and air-stable α-diimine palladium precatalysts were rationally designed, readily synthesized, and fully characterized. The relationship between the structures of the palladium complexes and the catalytic properties was investigated. It was revealed that the“bulky-yet-flexible”palladium complexes allowed highly anti-Markovnikov-selective

  为了进行高度区域选择性和高效的还原性Heck反应，合理设计，易于合成和充分表征了一系列湿气和空气稳定的α-二亚胺钯预催化剂。研究了钯配合物的结构与催化性能之间的关系。揭示了“大而尚柔的”钯配合物在好氧条件下可以使烯烃与（杂）芳基溴化物高度抗马尔科夫尼科夫选择性加氢芳基化。本方案的进一步合成应用可以提供对功能和生物活性分子的快速直接访问。
• Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp²–Csp³ bond formation
  作者：Liqun Jin、Jiaxia Qian、Nan Sun、Baoxiang Hu、Zhenlu Shen、Xinquan Hu

  DOI：10.1039/c8cc02571a

  日期：——

  We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp2–Csp3 bonds between aryl bromides and olefins. Various styrene derivatives, acyclic and cyclic alkenes, were well tolerated to couple with varied aryl bromides in linear selectivity. Kinetic and deuterium labeling experiments suggested that i-PrOH provides a hydride through β-H elimination.

  我们开发了Pd催化的分子间还原性Heck反应，以构建芳基溴化物和烯烃之间的Csp 2 -Csp 3键。各种苯乙烯衍生物（无环和环状烯烃）具有良好的耐受性，可以线性选择性地与各种芳基溴化物偶联。动力学和氘标记实验表明，i-PrOH可通过消除β-H来提供氢化物。
• THERMAL ACID GENERATORS AND PHOTORESIST PATTERN TRIMMING COMPOSITIONS AND METHODS
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20170123313A1

  公开（公告）日：2017-05-04

  Provided are ionic thermal acid generators of the following general formula (I): wherein: Ar 1 represents an optionally substituted carbocyclic or heterocyclic aromatic group; W independently represents a group chosen from carboxyl, hydroxy, nitro, cyano, C1-5 alkoxy and formyl; X is a cation; Y independently represents a linking group; Z independently represents a group chosen from hydroxyl, fluorinated alcohols, esters, optionally substituted alkyl, C5 or higher optionally substituted monocyclic, polycyclic, fused polycyclic cycloaliphatic, or aryl, which may optionally comprise a heteroatom, provided at least one occurrence of Z is a hydroxyl group; a is an integer of 0 or greater; b is an integer of 1 or greater; provided that a+b is at least 1 and not greater than the total number of available aromatic carbon atoms of the aromatic group. Also provided are photoresist pattern trimming compositions and methods of trimming a photoresist pattern using the trimming compositions. The thermal acid generators, compositions and methods find particular applicability in the manufacture of semiconductor devices.

  提供的是以下一般式(I)的离子热酸发生剂： 其中：Ar1代表一个可选取的取代的碳环或杂环芳香基团；W独立地代表从羧基，羟基，硝基，氰基，C1-5烷氧基和甲酰基中选择的一个基团；X是一个阳离子；Y独立地代表一个连接基团；Z独立地代表从羟基，氟化醇，酯类，可选取的取代烷基，C5或更高的可选取的单环，多环，融合多环环烷基或芳基中选择的一个基团，可以可选地包含一个杂原子，但至少有一个Z是一个羟基；a是大于或等于0的整数；b是大于或等于1的整数；但要求a+b至少为1且不大于芳香基团中可用的芳香碳原子的总数。此外，还提供了修剪光刻胶图案的组合物和方法。这些热酸发生剂、组合物和方法在半导体器件制造中具有特殊的适用性。
• Thermal acid generators and photoresist pattern trimming compositions and methods
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US10241407B2

  公开（公告）日：2019-03-26

  Provided are ionic thermal acid generators of the following general formula (I): wherein: Ar1 represents an optionally substituted carbocyclic or heterocyclic aromatic group; W independently represents a group chosen from carboxyl, hydroxy, nitro, cyano, C1-5 alkoxy and formyl; X is a cation; Y independently represents a linking group; Z independently represents a group chosen from hydroxyl, fluorinated alcohols, esters, optionally substituted alkyl, C5 or higher optionally substituted monocyclic, polycyclic, fused polycyclic cycloaliphatic, or aryl, which may optionally comprise a heteroatom, provided at least one occurrence of Z is a hydroxyl group; a is an integer of 0 or greater; b is an integer of 1 or greater; provided that a+b is at least 1 and not greater than the total number of available aromatic carbon atoms of the aromatic group. Also provided are photoresist pattern trimming compositions and methods of trimming a photoresist pattern using the trimming compositions. The thermal acid generators, compositions and methods find particular applicability in the manufacture of semiconductor devices.

  本文提供了以下通式（I）的离子热酸发生器： 其中Ar1 代表任选取代的碳环或杂环芳香基团； W 独立地代表选自羧基、羟基、硝基、氰基、C1-5 烷氧基和甲酰基的基团； X 是阳离子； Y 独立地代表连接基团；Z 独立地代表选自羟基、氟化醇、酯、任选取代的烷基、C5 或更高任选取代的单环、多环、融合多环环脂族或芳基的基团，其中可任选包含一个杂原子，条件是 Z 中至少有一个是羟基；a 是 0 或更大的整数；b 是 1 或更大的整数；条件是 a+b 至少为 1，且不大于芳香基团可用芳香碳原子的总数。此外，还提供了光刻胶图案修整组合物和使用修整组合物修整光刻胶图案的方法。这些热酸发生器、组合物和方法特别适用于半导体器件的制造。
• Benzene disulfonamide for the treatment of cancer
  申请人：Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.

  公开号：US10913710B2

  公开（公告）日：2021-02-09

  The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6δ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6δ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.

  本发明涉及新型取代苯二磺酰胺类化合物，以及含有至少一种此类取代苯二磺酰胺类化合物和至少一种药学上可接受的载体、赋形剂和/或稀释剂的药物组合物。所述取代苯二磺酰胺类药物与 PDE6δ 的芳基结合口袋结合，因此，通过抑制 PDE6δ 与法尼基化 Ras 蛋白的结合，从而抑制细胞中致癌的 Ras 信号传导，可用于预防和治疗癌症。