di(p-chlorophenyl)phosphinic amide | 83470-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di(p-chlorophenyl)phosphinic amide
• 英文别名: P,P-bis(4-chlorophenyl)phosphinic amide；1-[Amino-(4-chlorophenyl)phosphoryl]-4-chlorobenzene
• CAS: 83470-33-1
• 化学式: C₁₂H₁₀Cl₂NOP
• 分子量: 286.097
• InChiKey: TWDQJVKGFCZUMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Di-4-chlorphenyl-phosphinsaeure-chlorid 在 氨 作用下， 生成 di(p-chlorophenyl)phosphinic amide
  参考文献：
  名称：

  二芳基次膦叠氮化物：光化学反应，包括在甲醇中的重排

  摘要：

  DOI：

  10.1016/0040-4020(82)80240-8

文献信息

• Primary Amination of Ar₂P(O)–H with (NH₄)₂CO₃ as an Ammonia Source under Simple and Mild Conditions and Its Extension to the Construction of Various P–N or P–O Bonds
  作者：Yushi Tan、Ya-Ping Han、Yuecheng Zhang、Hong-Yu Zhang、Jiquan Zhao、Shang-Dong Yang

  DOI：10.1021/acs.joc.1c02933

  日期：2022.3.4

  reagents with stable and readily available ammonium carbonate as an ammonia source is disclosed herein for the first time. This ethyl bromoacetate-mediated primary amination proceeds smoothly under mild and simple conditions, without any metal catalyst or oxidant. Moreover, this method is also appropriate for the reaction of Ar2P(O)–H with a variety of amines, alcohols, and phenols to construct P–N or P–O

  本文首次公开了一种简便有效的方法，用于从 Ar 2 P(O)-H 试剂与稳定且易于获得的碳酸铵作为氨源合成伯膦酰胺。这种溴乙酸乙酯介导的伯胺化在温和简单的条件下顺利进行，无需任何金属催化剂或氧化剂。此外，该方法还适用于Ar 2 P(O)-H与多种胺类、醇类和酚类反应构建P-N或P-O键，操作方便，官能团耐受性好。 ，和广泛的底物范围。
• Chemodivergent Staudinger Reactions of Secondary Phosphine Oxides and Application to the Total Synthesis of LL–D05139β Potassium Salt
  作者：Wenjun Luo、Fang Xu、Zhenguo Wang、Jiyan Pang、Zixu Wang、Zhixiu Sun、Aiyun Peng、Xiaohui Cao、Le Li

  DOI：10.1002/anie.202310118

  日期：2023.10.9

  Unprecedented chemodivergent Staudinger reactions of secondary phosphine oxides (SPO) have been developed. Reagent-controlled 1- or 2-nitrogen atom exclusions from azides have been achieved. Conversion of a chiral SPO to a phosphinic amide was stereoretentive, and the potassium salt of natural product LL-D05139β was synthesized for the first time.

  二级氧化膦 (SPO) 史无前例的化学发散施陶丁格反应已经开发出来。已经实现了试剂控制的 1-或 2-氮原子从叠氮化物中的排除。手性SPO立体保留转化为次膦酰胺，首次合成了天然产物LL-D05139β的钾盐。
• Delta-hydroxy-beta-lysine derivatives and their production
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0271829A2

  公开（公告）日：1988-06-22

  compound of the formula wherein R' and R4 are independently amino or an organic residue bonded through nitrogen, R2 is hydrogen or alkyl which may be substituted, R3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R1 is amino, sorbylamino or hexanoylamino, R2 is hydrogen or methyl, R4 is amino which may be protected adn R5 is hydroxyl or 2-amidinoethylamino, R3 is a protecting group, and that when R1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R3 is hydrogen, methyl or 2-tettrahydropyranyl, R4 is amino, acetylamino or benzyloxycarbonylamino and R5 is hydroxyl which may be substituted or amino which may be substituted, R2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

  式中的化合物 其中 R' 和 R4 独立地为氨基或通过氮键合的有机残基，R2 为氢或可被取代的烷基，R3 为氢或保护基团，R5 为可被取代的羟基或可被取代的氨基或其盐；但当 R1 为氨基、山梨氨基或己酰氨基时，R2 为氢或甲基，R4 为可被保护的氨基，R5 为羟基或 2-脒乙基氨基，R3 为保护基；当 R1 为氨基、月桂氨基、乙酰氨基或苄氧羰基氨基时，R3 为氢、甲基或 2-四氢吡喃基、R4 是氨基、乙酰氨基或苄氧羰基氨基，R5 是羟基（可被取代）或氨基（可被取代），R2 是烷基（可被取代）时，具有抗耐药细菌的抗菌活性，因此可用作哺乳动物细菌感染的化疗药物。
• HARGER, M. J. P.;WESTLAKE, S., TETRAHEDRON, 1982, 38, N 10, 1511-1515
  作者：HARGER, M. J. P.、WESTLAKE, S.

  DOI：——

  日期：——
• US4906659A
  申请人：——

  公开号：US4906659A

  公开（公告）日：1990-03-06