2-amino-6-chloromethylpyridine | 1227588-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-6-chloromethylpyridine
• 英文别名: 6-(chloromethyl)pyridin-2-amine
• CAS: 1227588-28-4
• 化学式: C₆H₇ClN₂
• 分子量: 142.588
• InChiKey: NOERNKLWFKMUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-6-chloromethylpyridine 、 1,4,7-三(乙氧羟基甲基)-1,4,7,10-四阿扎环十四烷 在 potassium carbonate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Molecular Engineering of Self-Immolative Bioresponsive MR Probes

  摘要：

  DOI：

  10.1021/jacs.2c13672

文献信息

• PROCESS FOR PREPARATION OF t-BUTOXYCARBONYLAMINE COMPOUNDS
  申请人：Inoue Hiroki

  公开号：US20130005981A1

  公开（公告）日：2013-01-03

  Provided is a process for the preparation of t-butoxycarbonylamine compounds, which comprises using phosgene or a phosgene equivalent, t-butanol, and an organic base. Even when applied to a primary or secondary amine compound having low nucleophilicity, the process enables highly selective preparation of a t-butoxycarbonylamine compound at a low cost. In the process, a t-butoxycarbonylamine compound is prepared using: phosgene or a phosgene equivalent; t-butanol; an organic base; and either a primary or secondary amine compound or a primary or secondary ammonium salt.

  提供了一种制备叔丁氧羰胺化合物的方法，包括使用光气或光气等效物、叔丁醇和有机碱。即使应用于具有低亲核性的初级或次级胺化合物，该方法也能以较低成本实现对叔丁氧羰胺化合物的高选择性制备。在该过程中，使用光气或光气等效物、叔丁醇、有机碱以及初级或次级胺化合物或初级或次级铵盐来制备叔丁氧羰胺化合物。
• Process for preparation of t-butoxycarbonylamine compounds
  申请人：Inoue Hiroki

  公开号：US08653269B2

  公开（公告）日：2014-02-18

  Provided is a process for the preparation of t-butoxycarbonylamine compounds, which comprises using phosgene or a phosgene equivalent, t-butanol, and an organic base. Even when applied to a primary or secondary amine compound having low nucleophilicity, the process enables highly selective preparation of a t-butoxycarbonylamine compound at a low cost. In the process, a t-butoxycarbonylamine compound is prepared using: phosgene or a phosgene equivalent; t-butanol; an organic base; and either a primary or secondary amine compound or a primary or secondary ammonium salt.

  提供了一种制备t-叔丁氧羰基胺化合物的过程，其中包括使用光气或光气等效物、叔丁醇和有机碱。即使应用于具有低亲核性的一级或二级胺化合物，该过程也能以低成本实现高度选择性的t-叔丁氧羰基胺化合物制备。在该过程中，使用光气或光气等效物、叔丁醇、有机碱以及一级或二级胺化合物或一级或二级铵盐来制备t-叔丁氧羰基胺化合物。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2557078B1

  公开（公告）日：2016-03-23
• Novel Compound, Organic Cation Transporter 3 Detection Agent, And Organic Cation Transporter 3 Activity Inhibitor
  申请人：SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.

  公开号：US20160318886A1

  公开（公告）日：2016-11-03

  [Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound. [Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. R 1 -R 2 -R 3 -R 4 (A)
• US8653269B2
  申请人：——

  公开号：US8653269B2

  公开（公告）日：2014-02-18