ethyl 2-[N-(2-ethoxy-2-oxoethyl)-4-(3-methoxy-6-oxoxanthen-9-yl)-2-(pyridin-2-ylmethoxy)anilino]acetate | 1325206-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: ethyl 2-[N-(2-ethoxy-2-oxoethyl)-4-(3-methoxy-6-oxoxanthen-9-yl)-2-(pyridin-2-ylmethoxy)anilino]acetate
• CAS: 1325206-37-8
• 化学式: C₃₄H₃₂N₂O₈
• 分子量: 596.637
• InChiKey: BBHMSDVOZSAYAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  44
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  ethyl 2-[N-(2-ethoxy-2-oxoethyl)-4-(3-methoxy-6-oxoxanthen-9-yl)-2-(pyridin-2-ylmethoxy)anilino]acetate 在 lithium hydroxide monohydrate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以31%的产率得到2-[N-(carboxymethyl)-4-(3-methoxy-6-oxoxanthen-9-yl)-2-(pyridin-2-ylmethoxy)anilino]acetic acid
  参考文献：
  名称：

  Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

  摘要：

  A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.

  DOI：

  10.1021/ol201746p
• 作为产物：
  描述：

  2-氯甲基吡啶盐酸盐 在 甲烷磺酸 、 sodium hydride 、 potassium carbonate 、 三氟乙酸 、 potassium iodide 、 三氯氧磷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 ethyl 2-[N-(2-ethoxy-2-oxoethyl)-4-(3-methoxy-6-oxoxanthen-9-yl)-2-(pyridin-2-ylmethoxy)anilino]acetate
  参考文献：
  名称：

  Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

  摘要：

  A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.

  DOI：

  10.1021/ol201746p

文献信息

• Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane
  作者：Shohei Iyoshi、Masayasu Taki、Yukio Yamamoto

  DOI：10.1021/ol201746p

  日期：2011.9.2

  A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.