2-Methyl-1,1-ditosylpropan | 72834-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-1,1-ditosylpropan
• 英文别名: 1,1'-[(2-Methylpropane-1,1-diyl)disulfonyl]bis(4-methylbenzene)；1-methyl-4-[2-methyl-1-(4-methylphenyl)sulfonylpropyl]sulfonylbenzene
• CAS: 72834-71-0
• 化学式: C₁₈H₂₂O₄S₂
• 分子量: 366.502
• InChiKey: WGDDDQPEJCYMLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  双(对-甲苯磺酰)甲烷 、 N,N-Dimethyl-orthocarbamidsaeure-triisopropylester 生成 2-Methyl-1,1-ditosylpropan
  参考文献：
  名称：

  Kantlehner,W. et al., Liebigs Annalen der Chemie, 1979, p. 2096 - 2113

  摘要：

  DOI：

文献信息

• Sulfonylation of organometallic reagents with arenesulfonyl fluorides: a simple one-step synthesis of sulfones
  作者：Leah L. Frye、Eileen L. Sullivan、Kevin P. Cusack、John M. Funaro

  DOI：10.1021/jo00028a053

  日期：1992.1

  Sulfonylation of organometallic reagents was accomplished with arenesulfonyl fluorides to provide a wide variety of alkylaryl- and diaryl sulfones. Organolithium and diorganocopper lithium reagents react smoothly with arenesulfonyl fluorides to give sulfones in high yields. Alkyl Grignard reagents often lead to mixtures of monosulfonylated and disulfonylated products. However, allylmagnesium chloride and phenylmagnesium chloride provide the corresponding sulfones in excellent yields. Organocopper reagents were also found to yield sulfones upon treatment with arenesulfonyl fluorides. By utilizing this methodology, synthetically useful alkyl, (trimethylsilyl)methyl, and allyl sulfones are easily prepared in high yields.
• KANTLEHNER W.; JAUS H.; KIENITZ L.; BREDERECK H., LIEBIGS ANN. CHEM., 1979, NO 12, 2096-2113
  作者：KANTLEHNER W.、 JAUS H.、 KIENITZ L.、 BREDERECK H.

  DOI：——

  日期：——
• Kantlehner,W. et al., Liebigs Annalen der Chemie, 1979, p. 2096 - 2113
  作者：Kantlehner,W. et al.

  DOI：——

  日期：——