2-bromo-2-methylpropylamine hydrobromide | 36565-68-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-bromo-2-methylpropylamine hydrobromide
• 英文别名: Brom-2-methyl-2-propylamin-hydrobromid；1-Propanamine, 2-bromo-2-methyl-, hydrobromide；2-bromo-2-methylpropan-1-amine;hydrobromide
• CAS: 36565-68-1
• 化学式: BrH*C₄H₁₀BrN
• 分子量: 232.946
• InChiKey: OJUMFVSETXVFNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.59
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  对甲基苯甲醛 、 2-bromo-2-methylpropylamine hydrobromide 在 magnesium sulfate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以87%的产率得到
  参考文献：
  名称：

  A new route towards N-(α-methoxybenzyl)aziridines

  摘要：

  A new synthesis of N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines is presented. Different benzaldehydes were converted into the corresponding imines upon reaction with 2-bromo-2-methylpropylamine. Treatment of the latter imines with sodium methoxide afforded N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines in good yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02838-1
• 作为产物：
  描述：

  2,2-二甲基氮丙啶 在 氢溴酸 作用下， 以 水 为溶剂， 反应 6.0h， 生成 2-bromo-2-methylpropylamine hydrobromide
  参考文献：
  名称：

  A new route towards N-(α-methoxybenzyl)aziridines

  摘要：

  A new synthesis of N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines is presented. Different benzaldehydes were converted into the corresponding imines upon reaction with 2-bromo-2-methylpropylamine. Treatment of the latter imines with sodium methoxide afforded N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines in good yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02838-1

文献信息

• Visible-Light-Induced, Palladium-Catalyzed Annulation of 1,3-Dienes to Construct Vinyl <i>N</i>-Heterocycles
  作者：Yu Zheng、Weidong Lu、Zhenzhen Xie、Kai Chen、Haoyue Xiang、Hua Yang

  DOI：10.1021/acs.orglett.2c02101

  日期：2022.7.29

  Herein, a photoinduced palladium-catalyzed annulation of 1,3-dienes with bifunctional halognated alkylamines has been developed, offering a facile route to access a broad range of vinylpyrrolidines. The reactivity profile of this protocol was able to be readily manipulated to assemble vinylpyrrolidine and vinlysilaazacycle. Remarkably, the utility of this strategy was further illustrated in the construction

  在此，开发了一种光诱导钯催化的 1,3-二烯与双功能卤代烷基胺的环化反应，为获得广泛的乙烯基吡咯烷提供了一种简便的途径。该协议的反应特性能够很容易地操纵以组装乙烯基吡咯烷和 vinlysilaazacycle。值得注意的是，该策略的实用性在构建复杂且具有生物学重要性的分子以及所得产品的多样性导向转化中得到了进一步说明。
• Lamaty, Gerard; Sanchez, Jean-Yves; Sivade, Andre, Bulletin de la Societe Chimique de France, 1985, # 6, p. 1261 - 1266
  作者：Lamaty, Gerard、Sanchez, Jean-Yves、Sivade, Andre、Wylde, James

  DOI：——

  日期：——
• A new route towards N-(α-methoxybenzyl)aziridines
  作者：Matthias D'hooghe、Arn Hofkens、Norbert De Kimpe

  DOI：10.1016/s0040-4039(02)02838-1

  日期：2003.2

  A new synthesis of N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines is presented. Different benzaldehydes were converted into the corresponding imines upon reaction with 2-bromo-2-methylpropylamine. Treatment of the latter imines with sodium methoxide afforded N-(alpha-methoxyarylmethyl)-2,2-dimethylaziridines in good yields. (C) 2003 Elsevier Science Ltd. All rights reserved.