5,7-Dimethyl-naphthol-(1) | 31706-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5,7-Dimethyl-naphthol-(1)
• 英文别名: 5,7-Dimethyl-[1]naphthol；5,7-Dimethyl-1-naphthol；5,7-dimethylnaphthalen-1-ol
• CAS: 31706-76-0
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: ZMYBSCDKKBZCTM-UHFFFAOYSA-N

物化性质

• 沸点：
  323.5±11.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)
• 保留指数：
  1586

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,7-Dimethyl-naphthol-(1) 在 4-二甲氨基吡啶 、 N-溴代丁二酰亚胺(NBS) 、 silver sulfate 、 三乙胺 、 过氧化苯甲酰 作用下， 以 1,4-二氧六环 、 四氯化碳 、 二氯甲烷 、 水 为溶剂， 反应 3.67h， 生成 5,7-bis(hydroxymethyl)naphthalen-1-yl pivalate
  参考文献：
  名称：

  New repertoire of ‘donor-two-acceptor’ NIR fluorogenic dyes

  摘要：

  Dye molecules with various fluorescent wavelengths are widely used for diagnostic and optical imaging applications. Accordingly, there is a constant demand for fluorogenic dyes with new properties. We have recently developed a novel strategy for the design of long-wavelength fluorescent dyes with a turn-ON option. The design is based on a donor-two-acceptor pi-electron system that can undergo an internal charge transfer to form a new fluorochrome with an extended pi-conjugated system. Here, we describe a series of such dyes based on two novel latent donors, naphthol and hydroxycoumarin. One of the dyes has showed excellent near-infrared fluorescent characteristics and specifically was demonstrated as a mitochondrial imaging reagent in live cells. This unique strategy for fluorogenic dye design has opened new doors for further near-infrared fluorescence probe discovery. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.02.049
• 作为产物：
  描述：

  ((5,7-dimethyl-3,4-dihydronaphthalen-1-yl)oxy)trimethylsilane 在 四丁基氟化铵 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 2.5h， 生成 5,7-Dimethyl-naphthol-(1)
  参考文献：
  名称：

  New repertoire of ‘donor-two-acceptor’ NIR fluorogenic dyes

  摘要：

  Dye molecules with various fluorescent wavelengths are widely used for diagnostic and optical imaging applications. Accordingly, there is a constant demand for fluorogenic dyes with new properties. We have recently developed a novel strategy for the design of long-wavelength fluorescent dyes with a turn-ON option. The design is based on a donor-two-acceptor pi-electron system that can undergo an internal charge transfer to form a new fluorochrome with an extended pi-conjugated system. Here, we describe a series of such dyes based on two novel latent donors, naphthol and hydroxycoumarin. One of the dyes has showed excellent near-infrared fluorescent characteristics and specifically was demonstrated as a mitochondrial imaging reagent in live cells. This unique strategy for fluorogenic dye design has opened new doors for further near-infrared fluorescence probe discovery. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.02.049

文献信息

• Oxidative bromination of ketones using ammonium bromide and oxone®
  作者：Arun Kumar Macharla、Rohitha Chozhiyath Nappunni、Mahender Reddy Marri、Swamy Peraka、Narender Nama

  DOI：10.1016/j.tetlet.2011.11.011

  日期：2012.1

  esters and α,α-dibromination of 1,3-diketones and β-keto esters without catalyst is reported using ammonium bromide as a bromine source and oxone® as an oxidant. The reaction proceeds at ambient temperature and yields range from moderate to excellent. Bromination of unsymmetrical ketones takes place at the less substituted α-position predominantly. Aromatisation of tetralones is also carried out with this

  一种高效，环保，经济的方法，无需催化剂即可选择性地将芳烷基，环状，无环，1,3-二酮和β-酮​​酯进行α-单溴化，以及将1,3-二酮和β-酮​​酯进行α，α-二溴化使用溴化铵作为溴源和过硫酸氢钾报道®作为氧化剂。反应在环境温度下进行，收率范围从中等到极好。不对称酮的溴化主要发生在取代度较低的α位上。四氢萘酮的芳构化也用该试剂系统进行。
• HIGH-QUALITY BISPHENOL A AND PROCESS FOR PRODUCING THE SAME
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1149816A1

  公开（公告）日：2001-10-31

  The present invention is a high-quality bisphenol A wherein the content of sodium is not more than 80 ppb and the content of each element of the group A consisting of iron, nickel, chromium, manganese, lead, and molybdenum is not more than 50 ppb, or a high-quality bisphenol A containing an organic compound such as 9,9'-dimethylxanthene, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, 2,2,4-trimethylchromene, etc., in an amount of lower than a specific amount, and a preparation process of these high-quality bisphenol A. When an aromatic polycarbonate is prepared using the high-quality bisphenol of the invention, an aromatic polycarbonate which is not colored at the preparation thereof and molding the polycarbonate.

  本发明是一种高品质双酚 A，其中钠的含量不超过 80 ppb，由铁、镍、铬、锰、铅和钼组成的 A 组中每种元素的含量不超过 50 ppb，或者是一种高品质双酚 A，其中含有一种有机化合物，如 9,9'-二甲基呫吨、2-(4-羟基苯基)-2,4,4-三甲基苯并吡喃、2,2,4-三甲基苯并吡喃等，其含量低于特定量，以及这些高品质双酚 A 的制备工艺、使用本发明的优质双酚制备芳香族聚碳酸酯时，芳香族聚碳酸酯在制备和成型时不会着色。
• High quality bisphenol a and preparation process thereof
  申请人：——

  公开号：US20030028055A1

  公开（公告）日：2003-02-06

  The present invention is a high-quality bisphenol A wherein the content of sodium is not more than 80 ppb and the content of each element of the group A consisting of iron, nickel, chromium, manganese, lead, and molybdenum is not more than 50 ppb, or a high-quality bisphenol A containing an organic compound such as 9,9′-dimethylxanthene, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, 2,2,4-trimethyl-chromene, etc., in an amount of lower than a specific amount, and a preparation process of these high-quality bisphenol A. When an aromatic polycarbonate is prepared using the high-quality bisphenol of the invention, an aromatic polycarbonate which is not colored at the preparation thereof and molding the polycarbonate.

  本发明是一种优质双酚 A，其中钠的含量不超过 80 ppb，由铁、镍、铬、锰、铅和钼组成的 A 组中每种元素的含量不超过 50 ppb，或者是一种含有有机化合物的优质双酚 A，例如 9,9′-二甲基呫吨、2-(4-羟基苯基)-2,4,4-三甲基苯并吡喃、2,2,4-三甲基苯并吡喃等。,当使用本发明的优质双酚制备芳香族聚碳酸酯时，芳香族聚碳酸酯在制备和成型时不会着色。
• Petroleum asphalts modified by liquefied biomass additives
  申请人：——

  公开号：US20030212168A1

  公开（公告）日：2003-11-13

  Liquefied biomass ( 16 ) obtained from direct liquefaction and/or fast-pyrolysis is reacted with mixtures of fatty acids ( 24 ) in the presence of an oxidizer ( 28 ) and with various reactive monomer and polymer additives ( 46, 48, 50 ) to create tailored compatibilizer-like bio-additives ( 34 ) that are compatible with petroleum asphalts. By judiciously selecting appropriate additives and additional constituent, such as non-reactive ( 18 ) and reactive diluents ( 30 ), these bio-additives can be tailored to modify low-temperature properties, high-temperature properties, compatibility with aggregate materials, application characteristics, and other properties of petroleum asphalts for paving, roofing and sealing uses.

  液化生物质 ( 16 直接液化和/或快速热解得到的液化生物质与脂肪酸混合物( 24 ) 在氧化剂 ( 28 ) 以及各种活性单体和聚合物添加剂 ( 46, 48, 50 ) 来制造定制的类似于相容剂的生物添加剂 ( 34 与石油沥青兼容。通过明智地选择适当的添加剂和附加成分，如非反应性的生物添加剂 ( 18) 和生物添加剂 ( 19)。 18 ）和反应性稀释剂 ( 30 30 ），这些生物添加剂可以改变石油沥青的低温特性、高温特性、与骨料材料的兼容性、应用特性以及其他特性，以用于铺路、屋顶和密封用途。
• [EN] COAL BINDER PRODUCED BY LIQUEFACTION OF BIOMASS<br/>[FR] LIANT POUR CHARBON OBTENU PAR LIQUEFACTION DE LA BIOMASSE
  申请人：WASTE TECHNOLOGY TRANSFER, INC.

  公开号：WO1999029812A1

  公开（公告）日：1999-06-17

  (EN) A coal agglomerate is produced by the combination of coal fines (26) with bio-binder base (16) obtained from a biomass material (10) sized in a shredder (12) and processed by direct liquefaction in a liquefaction reactor (14) in the absence of oxygen at typical temperatures between about 230 and 370 degrees Centigrage and typical pressures between 200 and 3,000 psi, according to known liquefaction process. The liquefied bio-binder base (16) is mixed with fast pyrolysis tars (18) in mixer (20) or is mixed with petroleum asphalt (22) in mixer (24), if desired, in order to modify its characteristics to meet specific needs of particular applications, and the resulting mixture is sprayed on coal fines (26) preheated to at least 120 degrees Centigrade and allowed to react at about 150-205 degrees Centigrade. Combustible extenders and fillers (32), reinforcing fibers (34), and cross-linking agents (36) may be mixed with the coal fines (16) in reactor/mixer (28) prior to combination with the bio-binder base (16) to provide additional specific properties to the mixture. The resulting mixed mass is then pelletized by the application of pressure in a conventional coal pelletizer (30).(FR) Selon cette invention, on obtient un agglomérat de charbons en associant des fines de charbons (26) avec une base de biomasse (16) obtenue à partir d'une matière de biomasse (10) calibrée dans un broyeur (12) et traitée par liquéfaction directe dans un réacteur de liquéfaction (14), en l'absence d'oxygène et à des températures typiques comprises entre 230 et 370 degrés centigrade, et des pressions typiques comprises entre 200 et 3,000 psi, selon le procédé de liquéfaction connu. La base du bio-liant liquéfiée (16) est mélangée avec des goudrons de pyrolyse rapide (18) dans un premier mélangeur (20), ou avec du bitume de pétrole (22) dans un second mélangeur (24), si besoin est, afin de modifier ses caractéristiques et satisfaire les besoins spécifiques de certaines applications particulières, le mélange obtenu étant pulvérisé sur les fines de charbon (26) préchauffées à au moins 120 degrés centigrade et laissées à réagir à environ 150-205 degrés centigrade. On peut par ailleurs mélanger des charges (32), des fibres de renforcement (34) et des agents de réticulation (36) avec les fines de charbon (16) dans un réacteur/mélangeur (28) avant de les associer à la base du bio-liant (16),de façon à conférer au mélange des propriétés spécifiques supplémentaires. La masse mélangée obtenue est ensuite agglomérée en boulettes dans un granulateur de charbon classique (30).

  通过将煤粉（26）与生物质基粘结剂（16）组合，可以生产煤团聚体。生物质基粘结剂（16）是从经切碎机（12）粉碎的生物质材料（10），并在无氧条件下于典型温度（约230至370摄氏度）和典型压力（200至3,000磅/平方英寸）下通过直接液化反应器（14）处理得到。随后，将液化的生物质基粘结剂（16）与快速热解焦油（18）在混合机（20）中混合，或者根据需要将其与石油沥青（22）在混合机（24）中混合，以调整其特性以满足特定应用的需求。然后将此混合物喷洒到预热至至少120摄氏度的煤粉（26）上，并使其在约150-205摄氏度下反应。此外，在反应器/混合机（28）中可以预先与煤粉（16）混合燃烧延展剂和填充料（32）、增强纤维（34）以及交联剂（36），以提供额外的特定性质。最终得到的混合物通过在传统煤团聚机（30）上施加压力进行球化。 根据本发明，一种煤炭团聚体是通过将煤粉（26）与生物质基粘结剂（16）结合而制成的。该生物质基粘结剂（16）是从通过切碎机（12）处理的生物质材料（10），并在无氧条件下于典型的温度范围（约230至370摄氏度）和压力范围（200至3,000磅/平方英寸）下通过直接液化反应器（14）获得。然后，将液化的生物质基粘结剂（16）与快速热解焦油（18）在混合机（20）中混合，或者根据需要将其与石油沥青（22）在混合机（24）中混合，以调整其特性并满足特定应用的需求。随后将该混合物喷洒到预热至至少120摄氏度的煤粉（26）上，并使其在约150-205摄氏度下反应。此外，在反应器/混合机（28）中可以预先与煤粉（16）混合燃烧延展剂和填充料（32）、增强纤维（34）以及交联剂（36），以提供额外的特定性质。最终得到的混合物通过在传统煤炭团聚机（30）上施加压力进行球化。