1,1,1,3,3,5,5,5-八氟-2,2,4,4-四(三氟甲基)戊烷 | 62375-54-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 1,1,1,3,3,5,5,5-八氟-2,2,4,4-四(三氟甲基)戊烷
• 英文名称: Perfluor-2.2.4.4-tetramethyl-pentan
• 英文别名: 1,1,1,3,3,5,5,5-octafluoro-2,2,4,4-tetrakis-trifluoromethyl-pentane；perfluoro 2,2,4,4-tetramethylpentane；1,1,1,3,3,5,5,5-Octafluoro-2,2,4,4-tetrakis(trifluoromethyl)pentane
• CAS: 62375-54-6
• 化学式: C₉F₂₀
• 分子量: 488.067
• InChiKey: OBGZODCYKSYLOI-UHFFFAOYSA-N

物化性质

• 沸点：
  139.8±8.0 °C(Predicted)
• 密度：
  1.703±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  2,2,4,4-四甲基戊烷 在 fluorine 作用下， 生成 1,1,1,5,5,5-六氟-2,2,4,4-四-三氟甲基-戊烷 、 1,1,1,3,5,5,5-七氟-2,2,4,4-四-三氟甲基-戊烷 、 1,1,1,3,3,5,5,5-八氟-2,2,4,4-四(三氟甲基)戊烷
  参考文献：
  名称：

  Direct fluorination of 2,2,4,4-tetramethylpentane. Sterically protected residual protons?

  摘要：

  DOI：

  10.1021/jo00441a025

文献信息

• [EN] PERFLUOROCARBON-SOLUBLE COMPOUNDS<br/>[FR] COMPOSÉS SOLUBLES DANS DES PERFLUOROCARBONES
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2005107764A1

  公开（公告）日：2005-11-17

  The invention describes syntheses and purifications of several perfluorocarbon-soluble compounds having a general formula RF - L - X or RF - L - X - L - RF, wherein RF is a perfluorocarbon group, X is a hydrophilic moiety, and L is an amide linkage of general structure -CO-NH-. The invention also provides microemulsions comprising a PFC forming an oil phase, water or aqueous solution forming a water phase, and a PEG-based fluorosurfactant with an HFB (hydrophilic groups to fluorophilic groups balance) value from about 7 to about 13. The invention also provides a method of amidification of a fluorocompound. The method involves mixing perfluoracid chloride of a general formula CnF2n+1COCI with a compound containing an amine group with a general structure R-NH2 under reaction conditions sufficient to obtain a product having a general formula CnF2n+1-CONH-R.

  该发明描述了合成和纯化几种可溶于全氟碳化合物的化合物，其通用式为RF - L - X或RF - L - X - L - RF，其中RF是全氟碳基，X是亲水基团，L是一般结构为-CO-NH-的酰胺键。该发明还提供了微乳液，包括形成油相的PFC，形成水相的水或水溶液，以及具有HFB（亲水基团到亲氟基团平衡）值约为7至13的基于PEG的氟表面活性剂。该发明还提供了一种氟化合物的酰胺化方法。该方法涉及将通用式为CnF2n + 1COCI的全氟酸氯与含有一般结构为R-NH2的胺基团的化合物在足够的反应条件下混合，以获得通用式为CnF2n + 1-CONH-R的产物。
• Stable emulsions of highly fluorinated organic compound
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0231091A1

  公开（公告）日：1987-08-05

  Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly soluble in water, a surfactant and water.

  高氟有机化合物的稳定乳剂，可用作氧运输剂、"人造血液 "或红细胞替代物以及生物成像的造影剂。乳剂由高氟有机化合物、表面活性不强且不太溶于水的油类、表面活性剂和水组成。
• SELF-HEALING CROSS-LINKABLE SHELLS
  申请人：ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

  公开号：EP3563871A1

  公开（公告）日：2019-11-06

  The present invention relates to self-healing shells comprising a self-healing shell incorporating amphiphilic molecules having metal-coordinating group(s) reversibly cross-linked with metal cations.

  本发明涉及自愈合外壳，该外壳包含一种自愈合外壳，其中包含有与金属阳离子可逆交联的金属配位基团的两性分子。
• Composition for collecting and preserving placental stem cells and methods of using the composition
  申请人：Celularity, Inc.

  公开号：US10590381B2

  公开（公告）日：2020-03-17

  The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.

  本发明提供了从器官（如胎盘）采集干细胞的改进组合物和方法。本发明提供了一种干细胞采集组合物，该组合物包含细胞凋亡抑制剂和可选的酶，如蛋白酶或粘液溶解酶、血管扩张剂、坏死抑制剂、载氧全氟碳化合物或器官保存化合物。本发明提供了使用干细胞收集组合物收集干细胞和保存干细胞群的方法。
• Contrast agents
  申请人：NYCOMED IMAGING AS

  公开号：US20010019710A1

  公开（公告）日：2001-09-06

  Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.

  水包油型乳剂的油相中含有冷凝或溶解的油溶性气体/流体或气体前体，可用作超声造影剂。这类产品在储存状态下含有极少量的游离气泡或微泡，具有良好的稳定性，但可在给药前或给药后立即促进微泡的快速生成。