1-phenyl-hept-6-enylamine | 1073477-76-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-phenyl-hept-6-enylamine
• 英文别名: 1-Phenylhept-6-en-1-amine
• CAS: 1073477-76-5
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: NZXNIFAABAWNTC-UHFFFAOYSA-N

物化性质

• 沸点：
  298.5±29.0 °C(Predicted)
• 密度：
  0.926±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-phenyl-hept-6-enylamine 在 Hoveyda-Grubbs catalyst second generation 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 10.0h， 生成 (E)-benzyl (8-oxo-1-phenylnon-6-en-1-yl)carbamate
  参考文献：
  名称：

  Diastereoselective Control of Intramolecular Aza-Michael Reactions Using Achiral Catalysts

  摘要：

  An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) complex or strong Bronsted acid catalysis. A range of substrates undergoes these selective transformations. Functionalization of the resulting products yielding bicyclic heterocycles is also demonstrated.

  DOI：

  10.1021/ol202276h
• 作为产物：
  描述：

  magnesium,hex-1-ene,bromide 在 diphenyl phosphorazidite 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三苯基膦 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 12.0h， 生成 1-phenyl-hept-6-enylamine
  参考文献：
  名称：

  Diastereoselective Control of Intramolecular Aza-Michael Reactions Using Achiral Catalysts

  摘要：

  An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) complex or strong Bronsted acid catalysis. A range of substrates undergoes these selective transformations. Functionalization of the resulting products yielding bicyclic heterocycles is also demonstrated.

  DOI：

  10.1021/ol202276h

文献信息

• PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Boyle Craig D.

  公开号：US20100190687A1

  公开（公告）日：2010-07-29

  The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 (“GPR119”) in a patient.

  本发明涉及嘧啶酮衍生物，包含嘧啶酮衍生物的组合物，以及使用嘧啶酮衍生物治疗或预防肥胖、糖尿病、代谢紊乱、心血管疾病或与G蛋白偶联受体119（“GPR119”）活性相关的疾病的方法。
• Bexrud, Jason A.; Eisenberger, Patrick; Leitch, David C., Journal of the American Chemical Society, 2009, vol. 131, p. 2116 - 2118
  作者：Bexrud, Jason A.、Eisenberger, Patrick、Leitch, David C.、Payne, Philippa R.、Schafer, Laurel L.

  DOI：——

  日期：——
• [EN] PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉES DE PYRIMIDINONE, ET LEURS MÉTHODES D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2008130581A1

  公开（公告）日：2008-10-30

  [EN] The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.
  [FR] L'invention porte sur des dérivées de pyrimidinone, des compositions les comprenant et leurs méthodes d'utilisation pour traiter ou empêcher: l'obésité, le diabète, des troubles du métabolisme, des maladies cardiovasculaires ou des dysfonctionnements liés à l'activité du récepteur couplé à la protéine G 119 ("GPR119") chez un patient.
• Diastereoselective Control of Intramolecular Aza-Michael Reactions Using Achiral Catalysts
  作者：Cheng Zhong、Yikai Wang、Alvin W. Hung、Stuart L. Schreiber、Damian W. Young

  DOI：10.1021/ol202276h

  日期：2011.10.21

  An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) complex or strong Bronsted acid catalysis. A range of substrates undergoes these selective transformations. Functionalization of the resulting products yielding bicyclic heterocycles is also demonstrated.