(6R,6aS,14aR)-methyl 12-(4-fluorophenyl)-1,6,8,12,14a-pentahydroxy-11-((2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-ylamino)-6a-methoxy-3-methyl-7,9,14-trioxo-5,6,6a,7,9,12,14,14a-octahydrobenzo[a]tetracene-2-carboxylate | 1353658-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: (6R,6aS,14aR)-methyl 12-(4-fluorophenyl)-1,6,8,12,14a-pentahydroxy-11-((2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-ylamino)-6a-methoxy-3-methyl-7,9,14-trioxo-5,6,6a,7,9,12,14,14a-octahydrobenzo[a]tetracene-2-carboxylate
• 英文别名: methyl (6R,6aS,14aR)-12-(4-fluorophenyl)-1,6,8,12,14a-pentahydroxy-11-[[(2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl]amino]-6a-methoxy-3-methyl-7,9,14-trioxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate
• CAS: 1353658-64-6
• 化学式: C₄₀H₄₀FNO₁₅
• 分子量: 793.754
• InChiKey: AROPWXOPJPVDLW-CYQZUNDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  57
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  248
• 氢给体数：
  7
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  (6R,6aS,14aR)-methyl 1,6,8,14a-tetrahydroxy-11-((2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-ylamino)-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6,6a,7,9,12,14,14a-octahydrobenzo[a]tetracene-2-carboxylate 、 4-氟苯基溴化镁 在 氮气 、 水 、 二氯甲烷 、 Brine 、 Sodium sulfate-III 、 crude material 、 acetonitrile-water 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 以isocratic) to afford (6R,6aS,14aR)-methyl 12-(4-fluorophenyl)-1,6,8,12,14a-pentahydroxy-11-((2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-ylamino)-6a-methoxy-3-methyl-7,9,14-trioxo-5,6,6a,7,9,12,14,14a-octahydrobenzo[a]tetracene-2-carboxylate as a diastereomer A (13 mg, 7%)的产率得到(6R,6aS,14aR)-methyl 12-(4-fluorophenyl)-1,6,8,12,14a-pentahydroxy-11-((2S,3R,4R,5R,6S)-4-hydroxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-ylamino)-6a-methoxy-3-methyl-7,9,14-trioxo-5,6,6a,7,9,12,14,14a-octahydrobenzo[a]tetracene-2-carboxylate
  参考文献：
  名称：

  Antibacterial compounds, methods of making them, and uses thereof

  摘要：

  本发明涉及具有抗菌活性的新型治疗药物、其制备过程以及含有其作为活性成分的制药、兽医和营养组合物。本发明还涉及新型治疗药物的用途，例如作为药剂或食品添加剂用于治疗细菌感染或促进受试者体重增加。

  公开号：

  US08754054B2

文献信息

• Antibacterial compounds, methods of making them, and uses thereof
  申请人：Carr Grant J.

  公开号：US08754054B2

  公开（公告）日：2014-06-17

  The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.

  本发明涉及具有抗菌活性的新型治疗药物、其制备过程以及含有其作为活性成分的制药、兽医和营养组合物。本发明还涉及新型治疗药物的用途，例如作为药剂或食品添加剂用于治疗细菌感染或促进受试者体重增加。
• US8754054B2
  申请人：——

  公开号：US8754054B2

  公开（公告）日：2014-06-17
• [EN] NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS ANTIBACTÉRIENS, PROCÉDÉS DE FABRICATION DE CEUX-CI, ET UTILISATIONS DE CEUX-CI
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2012006321A2

  公开（公告）日：2012-01-12

  The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
• NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
  申请人：CARR GRANT J.

  公开号：US20120010163A1

  公开（公告）日：2012-01-12

  The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.

  本发明涉及具有抗菌活性的新型治疗药物，其制备过程以及包含它们作为活性成分的药用、兽医和营养组合物。本发明还涉及新型治疗药物的用途，例如，作为药物或食品添加剂用于治疗细菌感染或帮助受试者增加体重。