Pure white solid without appreciable odor. Used as an insecticide to protect cotton, fruit, vegetables and field crops. Not registered as a pesticide in the U.S. (EPA, 1998)
颜色/状态：
White crystalline solid
气味：
Odorless
蒸汽压力：
4.4X10-3 mm Hg at 25 °C /Estimated/
稳定性/保质期：
This cmpd is stable to heat, light, & hydrolysis under normal conditions.
分解：
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
When rats were exposed to labeled UC-10854, labeled (14)C-carbon dioxide was formed. After incubation of rat liver microsomes with UC-10854 in the presence of reduced nicotinamide--adenine dinucleotide phosphate (NADPH), 3-(1-hydroxy-1-methylethyl)phenyl methylcarbamate & 3-isopropyl N-hydroxymethylcarbamate were observed. Several unidentified compounds were also found.
Studies conducted with UC-10854 labeled (14)C-CH3 & (14)C-C=O showed that (14)C-carbon dioxide arose from both in treated houseflies. Houseflies also hydrolyzed this material to the corresponding phenol.
来源:Hazardous Substances Data Bank (HSDB)
代谢
在用UC-10854处理豆科植物后，除了几种未识别的化合物外，还发现了羟基丙基和N-羟甲基类似物。
After treatment of bean plants with UC-10854, in addition to several unidentified compounds, the hydroxypropyl & N-hydroxymethyl analogs were found.
The meta-isomer of isoprocarb (m-isopropylphenyl N-methylcarbamate) is much more toxic to animals /than the ortho-isomer/ ... Perhaps its higher toxicity is due to its metabolism by side chain oxidation to yield (1-hydroxy-1-methylethyl)phenyl methylcarbamate, which is also a cholinesterase inhibitor.
m-Cumenyl methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.
来源:Toxin and Toxin Target Database (T3DB)
毒理性
致癌物分类
对人类不具有致癌性（未被国际癌症研究机构IARC列名）。
No indication of carcinogenicity to humans (not listed by IARC).
Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, increased bronchial secretions, increased salivation, lacrimation, sweating, peristalsis, and urination can occur. Chronically high (>10 years) exposure leads to neuropsychological consequences including disturbances in perception and visuo-motor processing (A15321).
As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (L795)
Little information is available on the distribution of carbamates in the various organs and tissues in mammals following exposure by inhalation or the oral route. The organs in which residues have been reported are the liver, kidneys, brain, fat, and muscle. The half-life in the rat is of the order of 3-8 hr. It seems that the excretion of carbamates via urine is also rapid in man, and that the metabolic pathways in man are the same as those in the rat. /Carbamate pesticides/
In vivo studies have shown that carbamates are almost completely absorbed during normal transit through the gastrointestinal tract. ...In mice, all carbamates were rapidly distributed to the tissues and organs. The half-life values of penetration ranged from 8-17 min for carbamates. ...In animals, oxidation of carbamates often, but not always, results in detoxification. Oxidative metabolism generally leads to products of greater polarity and water solubility, and these can be more readily eliminated through the urine and feces than the parent compound. /Carbamate pesticides/
Process for preparing N-[(phosphinyl)amino]thio- and N-[(phosphinyl)amino]t
申请人：The Upjohn Company
公开号：US04201733A1
公开（公告）日：1980-05-06
Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-](phosphinothioyl)amino]thio-methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)-amino]thio-methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.
N-[(phosphinyl or phosphinothioyl)amino]thio-methylcarbamates and
申请人：The Upjohn Company
公开号：US04208409A1
公开（公告）日：1980-06-17
Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)amino]thio- methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[(phosphinothioyl)amino]thio- methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.
Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)amino]thio- methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[phosphinyl)amino]thio- and N-[(phosphinothioyl)-amino]thio- methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.
A novel class of chemical compounds useful as pesticides consists of N-alkoxy- and N-aryloxysulfinylcarbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.
A novel class of chemical compounds useful as pesticides consists of N-alkylsulfonyl-, N-arylsulfonyl-, and N-aminosulfonylaminosulfinylcarbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.
