5-hydroxy-7-methyl-2,3-dihydrothiazo<4,5-b>pyridin-2-one | 128294-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-hydroxy-7-methyl-2,3-dihydrothiazo<4,5-b>pyridin-2-one
• 英文别名: 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one；5-hydroxy-7-methylthiazolo[4,5-b]pyridin-2(3H)-one；7-Methyl-thiazolo[4,5-B]pyridine-2,5(3H,4H)-dione；7-methyl-3,4-dihydro-[1,3]thiazolo[4,5-b]pyridine-2,5-dione
• CAS: 128294-07-5
• 化学式: C₇H₆N₂O₂S
• 分子量: 182.203
• InChiKey: INVNPUJICRQBLR-UHFFFAOYSA-N

物化性质

• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-hydroxy-7-methyl-2,3-dihydrothiazo<4,5-b>pyridin-2-one 在 sodium hydroxide 作用下， 以60%的产率得到5-hydroxy-7-methyl-2,3-dihydrothiazo<4,5-b>pyridin-2-one sodium salt
  参考文献：
  名称：

  ynthesis, Anti-Inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]Pyridines

  摘要：

  5-Hydroxy-7-methyl-3H-thiazolo [4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C-5 and C-6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

  DOI：

  10.17344/acsi.2018.4570
• 作为产物：
  描述：

  4-氨基-1,3-噻唑-2(5H)-酮 、 乙酰乙酸乙酯 在 甲醇 、 sodium 作用下， 反应 72.0h， 以88%的产率得到5-hydroxy-7-methyl-2,3-dihydrothiazo<4,5-b>pyridin-2-one
  参考文献：
  名称：

  4-亚氨基噻唑烷酮-2与乙酰乙酸酯的反应

  摘要：

  DOI：

  10.1007/bf00481527

文献信息

• Reaction of 4-iminothiazolidinone-2 with acetoacetic ester
  作者：I. D. Komaritsa

  DOI：10.1007/bf00481527

  日期：1989.11
• 10.17344/acsi.2020.5439
  作者：Chaban, Ihor G.、Chaban, Taras I.、Matiichuk, Yulia E.、Matiychuk, Vasyl S.、Nektegayev, Ihor A.、Ogurtsov, Volodymyr V.、Shyyka, Olga Ya.

  DOI：10.17344/acsi.2020.5439

  日期：——
• KOMARITSA, I. D., XIMIYA GETEROTSIKL. SOED.,(1989) N1, S. 1547-1549
  作者：KOMARITSA, I. D.

  DOI：——

  日期：——
• ynthesis, Anti-Inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]Pyridines
  作者：Taras I. Chaban、Volodymyr V. Ogurtsov、Vasyl S. Matiychuk、Ihor G. Chaban、Inna L. Demchuk、Ihor A. Nektegayev

  DOI：10.17344/acsi.2018.4570

  日期：——

  5-Hydroxy-7-methyl-3H-thiazolo [4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C-5 and C-6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.